Catalytic asymmetric nitroaldol reaction of α,α-difluoro aldehydes mediated by rare earth-lithium-BINOL complexes

Article abstract of DOI:10.1016/S0040-4039(96)02090-4

Rare earth-Li-BINOL complexes were used to catalyze nitroaldol reactions of α,α-difluoro aldehydes with nitromethane in a good enantioselective manner. The optical yields of nitroaldol 2a depend on the size of rare earth metals, and an Sm-Li-BINOL complex