192718-06-2

Basic information

• Product Name: 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
• Synonyms: 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione;C527
• CAS NO: 192718-06-2
• Molecular Formula: C17H8FNO3
• Molecular Weight: 293.2487232
• Mol File: 192718-06-2.mol

Chemical Properties

• Boiling Point: 488.6±47.0 °C(Predicted)
• Appearance: faint yellow to dark yellow/
• Density: 1.433±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble0.3mg/mL, clear (warmed)
• PKA: -4.21±0.20(Predicted)
• CAS DataBase Reference: 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione(192718-06-2)
• EPA Substance Registry System: 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione(192718-06-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 46
• WGK Germany: 3
• Hazardous Substances Data: 192718-06-2(Hazardous Substances Data)

Usage

Core structure

Naphtho-oxazole core

Substituent

Fluorophenyl group

Usage

Pharmaceutical and research applications

Therapeutic properties

Antiviral, antibacterial, and anticancer activities

Chemical probe

Used to study cellular processes and pathways

Molecular structure

Valuable tool in medicinal and pharmaceutical chemistry.

Upstream product

• 7208-14-2 2-amino-3-bromo-1,4-naphthoquinone 
• 403-43-0 4-fluorobenzoyl chloride 
• 2797-51-5 quinoclamine 

Relevant articles and documents

Synthesis and cytotoxic activities of some 2-Arylnaphtho [2,3-d]oxazole-4,9-dione derivatives on androgen-dependent (LNCaP) and androgen-independent (PC3) human prostate cancer cell lines

The synthesis of five 2-arylnaphtho[2,3-d]oxazole- 4,9-dione derivatives was accomplished by refluxing 2-amino-3-bromo-1,4-naphthoquinone with appropriate benzoyl chloride analogs at elevated temperatures. In vitro anticancer evaluation of these compounds

Use of tricyclic derivatives of 1,4-dihydro-1,4-dioxo-1H-naphthalene, novel compounds obtained and their application in theraphy

The invention concerns the therapeutic use of tricyclic salts and their pharmaceutically acceptable salts having the general formula: in which: A is either a sulfur atom, an oxygen atom, or an R3N radical where R3is a hydrogen atom,