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2-Amino-5-(benzyloxy)-4-methoxybenzonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 192869-57-1 Structure
  • Basic information

    1. Product Name: 2-Amino-5-(benzyloxy)-4-methoxybenzonitrile
    2. Synonyms: 2-Amino-5-(benzyloxy)-4-methoxybenzonitrile
    3. CAS NO:192869-57-1
    4. Molecular Formula: C15H14N2O2
    5. Molecular Weight: 254.28
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 192869-57-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 452.32°C at 760 mmHg
    3. Flash Point: 227.355°C
    4. Appearance: /
    5. Density: 1.222g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.612
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 1.95±0.10(Predicted)
    11. CAS DataBase Reference: 2-Amino-5-(benzyloxy)-4-methoxybenzonitrile(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2-Amino-5-(benzyloxy)-4-methoxybenzonitrile(192869-57-1)
    13. EPA Substance Registry System: 2-Amino-5-(benzyloxy)-4-methoxybenzonitrile(192869-57-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 192869-57-1(Hazardous Substances Data)

192869-57-1 Usage

Physical state

white to off-white solid

Solubility

slightly soluble in water, more soluble in organic solvents

Molecular weight

277.3 g/mol

Common uses

intermediate in pharmaceutical and organic compound synthesis

Potential applications

pharmaceutical and chemical industries

Versatility

used in production of drugs and other chemical products

Check Digit Verification of cas no

The CAS Registry Mumber 192869-57-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,8,6 and 9 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 192869-57:
(8*1)+(7*9)+(6*2)+(5*8)+(4*6)+(3*9)+(2*5)+(1*7)=191
191 % 10 = 1
So 192869-57-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H14N2O2/c1-18-14-8-13(17)12(9-16)7-15(14)19-10-11-5-3-2-4-6-11/h2-8H,10,17H2,1H3

192869-57-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-4-methoxy-5-phenylmethoxybenzonitrile

1.2 Other means of identification

Product number -
Other names 2-amino-5-benzyloxy-4-methoxybenzonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:192869-57-1 SDS

192869-57-1Relevant articles and documents

4-anilinoquinazoline derivative and albumin conjugates thereof

-

Page/Page column 6, (2019/04/26)

a pharmaceutical composition for preventing, treating, or ameliorating one or more symptoms of a malignant tumor associated with EGFR mutation and/or K-RAS mutation is provided. The pharmaceutical composition includes a 4-anilinoquinazoline derivative having a formula (I) where A is iodine when m is 1 and n is zero, or A is albumin when m is an integral ranging from 1 to 7 and n is 1.

Synthesis and biological assay of erlotinib analogues and BSA-conjugated erlotinib analogue

Boobalan, Ramalingam,Liu, Kuang-Kai,Chao, Jui-I.,Chen, Chinpiao

supporting information, p. 1784 - 1788 (2017/04/04)

A series of erlotinib analogues that have structural modification at 6,7-alkoxyl positions is efficiently synthesized. The in vitro anti-tumor activity of synthesized compounds is studied in two non-small cell lung cancer (NSCLC) cell lines (A549 and H1975). Among the synthesized compounds, the iodo compound 6 (ETN-6) exhibits higher anti-cancer activity compared to erlotinib. An efficient method is developed for the conjugation of erlotinib analogue-4, alcohol compound, with protein, bovine serum albumin (BSA), via succinic acid linker. The in vitro anti-tumor activity of the protein attached erlotinib analogue, 8 (ETN-4-Suc-BSA), showed stronger inhibitory activity in both A549 and H1975 NSCLC cell lines.

PROCESS FOR PREPARING QUINAZOLINE DERIVATIVE

-

, (2016/01/01)

A concise, efficient and cost-and time-saving process for the preparation of a quinazoline derivative of formula (A) given below: which is an intermediate for making gefitinib or gefitinib itself, comprising reacting a compound of formula (B): with 3-chloro-4-fluoroaniline (VI) in the presence of a N,N-dialkyl formamide acetal, a Bronsted acid catalyst, and a solvent in a one-pot reaction.

Optimization of gefitinib analogues with potent anticancer activity

Yin, Kai-Hao,Hsieh, Yi-Han,Sulake, Rohidas S.,Wang, Su-Pei,Chao, Jui-I.,Chen, Chinpiao

supporting information, p. 5247 - 5250 (2015/01/08)

The interactions of gefitinib (Iressa) in EGFR are hydrogen bonding and van der Waals forces through quinazoline and aniline rings. However the morpholino group of gefitinib is poorly ordered due to its weak electron density. A series of novel piperazino analogues of gefitinib where morpholino group substituted with various piperazino groups were designed and synthesized. Most of them indicated significant anti-cancer activities against human cancer cell lines. In particular, compounds 52-54 showed excellent potency against cancer cells. Convergent synthetic approach has been developed for the synthesis of gefitinib intermediate which can lead to gefitinib as well as numerous analogues.

Quinoline and quinazoline compounds useful in therapy

-

, (2008/06/13)

Compounds of formula I, wherein R1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 represents an aryl group or a heteroaryl group, optionally substituted by C1-4 alkyl or SO2

Quinolines and quinazolines useful in therapy

-

, (2008/06/13)

Compounds of formula I, wherein R1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 and R3 independently represent H or C1-6 alkoxy (which is optionally substituted); R4 represents a 4-, 5-, 6- or 7-membered heterocyclic rin

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