19293-63-1Relevant articles and documents
KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
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Page/Page column 99, (2011/10/31)
The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are a pharmaceutical composition and method of use thereof.
BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS
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Page/Page column 162, (2009/12/27)
The present invention relates to Bicyclic Heterocycle Derivatives of formula (I), compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR1 19 in a patient.
Mapping the active site in a chemzyme: Diversity in the N-substituent in the catalytic asymmetric aziridination of imines
Zhang, Yu,Lu, Zhenjie,Desai, Aman,Wulff, William D.
supporting information; experimental part, p. 5429 - 5432 (2009/06/20)
(Chemical Equation Presented) The active site of the aziridination catalyst derived from either the VANOL or VAPOL ligand and B(OPh)3 is larger than expected and can accommodate not only significant substitution on the diarylmethyl unit of the imine but also that alkyl (but not perfluorylalkyl) substituents on the aryl groups lead to enhanced rates and enantioselection. The screen of diarylmethyl N-substituents on the imine revealed that the 3,5-di-tert-butyldianisylmethyl group (BUDAM) gave exceptionally high asymmetric inductions for imines of aryl aldehydes.
Matrix metalloproteinase inhibitors
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, (2008/06/13)
A compound, which is an amine derivative of formula (I) wherein W is —CNHOH or —COOH: R1and R2are each hydrogen or an organic residue, R3is an organic group, Q is a secondary or tertiary acyclic or cyclic amido group, and
Atroposelectivity in the reactions of ortholithiated aromatic tertiary amides with aldehydes
Bowles, Peter,Clayden, Jonathan,Helliwell, Madeleine,McCarthy, Catherine,Tomkinson, Matthew,Westlund, Neil
, p. 2607 - 2616 (2007/10/03)
The products of the addition of ortholithiated N,N-dialkylnaphthamides to aldehydes are pairs of stable, diastereoisomeric atropisomers, formed with selectivities of up to 90:10 in favour of the syn-atropisomer.