(-)-Fumagillol (2), a hydrolysis product of fumagillin (1), has been synthesized in a highly stereoselective manner utilizing a glycolate Claisen rearrangement and an intramolecular ester enolate alkylation as key steps starting from carbohydrate-based precursor 5.
Kim, Deukjoon,Ahn, Soon Kil,Bae, Hoon,Choi, Won Jun,Kim, Hak Sung