An asymmetric total synthesis of (-)-fumagillol

DOI: 10.1016/S0040-4039(97)00925-8

Source and publish data:

Tetrahedron Letters p. 4437 - 4440 (1997)

Update date:2022-07-31

Topics:

Authors:

Kim, Deukjoon

Ahn, Soon Kil

Bae, Hoon

Choi, Won Jun

Kim, Hak Sung

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Article abstract of DOI:10.1016/S0040-4039(97)00925-8

(-)-Fumagillol (2), a hydrolysis product of fumagillin (1), has been synthesized in a highly stereoselective manner utilizing a glycolate Claisen rearrangement and an intramolecular ester enolate alkylation as key steps starting from carbohydrate-based precursor 5.

Full text of DOI:10.1016/S0040-4039(97)00925-8

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