193611-28-8

Basic information

• Product Name: 2-tert-Butyl-4-chloro-6-trifluoroMethyl-pyriMidine
• Synonyms: 2-tert-Butyl-4-chloro-6-trifluoroMethyl-pyriMidine;2-t-butyl-4-chloro-6-trifluoromethylpyrimidine;4-Chloro-2-(1,1-dimethylethyl)-6-(trifluoromethyl)pyrimidine
• CAS NO: 193611-28-8
• Molecular Formula: C₉H₁₀ClF₃N₂
• Molecular Weight: 238.6373096
• Mol File: 193611-28-8.mol

Chemical Properties

• Boiling Point: 219°C at 760 mmHg
• Flash Point: 86.3°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 0.18mmHg at 25°C
• Refractive Index: 1.451
• Storage Temp.: 2-8°C
• Solubility: Chloroform, DCM, DMF
• CAS DataBase Reference: 2-tert-Butyl-4-chloro-6-trifluoroMethyl-pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-Butyl-4-chloro-6-trifluoroMethyl-pyriMidine(193611-28-8)
• EPA Substance Registry System: 2-tert-Butyl-4-chloro-6-trifluoroMethyl-pyriMidine(193611-28-8)

Safety Data

• Hazardous Substances Data: 193611-28-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-tert-Butyl-4-chloro-6-trifluoroMethyl-pyriMidine is used as an intermediate in the synthesis of ABT 925 Fumerate (A112600), which is a dopamine D3 receptor antagonist. 2-tert-Butyl-4-chloro-6-trifluoroMethyl-pyriMidine plays a significant role in the development of medications for the treatment of acute schizophrenia, as it helps modulate the activity of dopamine D3 receptors, potentially leading to improved symptoms management and overall patient outcomes.

InChI:InChI=1/C9H10ClF3N2/c1-8(2,3)7-14-5(9(11,12)13)4-6(10)15-7/h4H,1-3H3

Upstream product

• 193610-95-6 2-(1,1-dimethylethyl)-6-trifluoromethylpyrimidin-4-ol 

Downstream Products

• 1596371-68-4 1-benzyl-N-(4-(4-(2-(tert-butyl)-6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)butyl)piperidine-4-carboxamide 
• 1596371-66-2 N-(4-(4-(2-(tert-butyl)-6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)butyl)-1-phenylpiperidine-4-carboxamide 
• 219599-99-2 2-t-Butyl-4-(1-piperazinyl)-6-trifluoromethylpyrimidine 
• 198078-86-3 Benzyl 2-(2-tert-butyl-6-trifluoromethyl-4-pyrimidinyloxy)-3-methoxy-3,3-diphenylpropionate 

Relevant articles and documents

PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL

A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

2-{3-[4-(2-T-butyl-6-trifluoromethyl-4-pyrimidinyl)-1- piperazinyl] propylthio}-4-pyrimidinol fumarate

The fumaric acid salt of 2-{3-[4-(2-t-butyl-6-trifluoromethyl-4-pyrimidinyl)-1-piperazinyl]propylthio}-4-pyrimidinol is useful for treating disorders which respond to dopamine D3 ligands. It has higher stability at low pH and is therefore particularly suitable for oral administration in pharmaceutical compositions comprising this salt.

2-{3-[4-(2-t-butyl-6-trifluoromethyl-4-pyrimidinyl)-1- piperazinyl] propylthio}-4-pyrimidinol fumarate

The fumaric acid salt of 2-{3-[4-(2-t-butyl-6-trifluoromethyl-4-pyrimidinyl)-1-piperazinyl]propylthio}-4-pyrimidinol is useful for treating disorders which respond to dopamine D3ligands. It has higher stability at low pH and is therefore particularly suitable for oral administration in pharmaceutical compositions comprising this salt.

Substituted AZA- and diazacycloheptane and -cyclooctane

Aza- and diazacyclohexane and -cyclooctane compounds of the following formula: Ar1—A—B—Ar2??(I) where Ar1, A, B and Ar2have the meanings stated in the description have a high affinity for the dopamine D3/s

2{3-[4-(2-T-BUTYL-6-TRIFLUOROMETHYLPYRIDIN-4-YL) PIPERAZIN-1-YL] PROPYLMERCAPTO} PYRIMIDIN-4-OL-FUMARATE

The fumaric acid salt of 2-{3-[4-(2-t-butyl-6-trifluoromethyl-4-pyrimidinyl)-1-piperazinyl]propylthio}-4-pyrimidinol is useful for treating disorders which respond to dopamine D3 ligands. It has higher stability at low pH and is therefore particularly suitable for oral administration in pharmaceutical compositions comprising this salt.