193610-95-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(1,1-DIMETHYLETHYL)-6-(TRIFLUOROMETHYL)-4(1H)-PYRIMIDINONE is used as an intermediate in the synthesis of ABT 925 Fumarate (A112600), which is a dopamine D3 receptor antagonist. 2-(1,1-DIMETHYLETHYL)-6-(TRIFLUOROMETHYL)-4(1H)-PYRIMIDINONE plays a significant role in the treatment of acute schizophrenia by modulating the dopaminergic system, thereby helping to alleviate the symptoms associated with the condition.

InChI:InChI=1/C9H11F3N2O/c1-8(2,3)7-13-5(9(10,11)12)4-6(15)14-7/h4H,1-3H3,(H,13,14,15)

Upstream product

• 83643-84-9 methyl 4,4,4-trifluoroacetoacetate 
• 18202-73-8 pivalamidine hydrochloride 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 59950-56-0 pivalimidamide 

Downstream Products

• 193611-28-8 2-t-butyl-4-chloro-6-trifluoromethylpyrimidine 

Relevant academic research and scientific papers

PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL

A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

THIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS

The invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, which are antagonist of the CXCR3 chemokine receptor useful for the treatment or prevention of pathogenic inflammatory processes, autoimmune diseases or graft rejection processes. Methods of use and pharmaceutical compositions are also encompassed.

Substituted AZA- and diazacycloheptane and -cyclooctane

Aza- and diazacyclohexane and -cyclooctane compounds of the following formula: Ar1—A—B—Ar2??(I) where Ar1, A, B and Ar2have the meanings stated in the description have a high affinity for the dopamine D3/s

2{3-[4-(2-T-BUTYL-6-TRIFLUOROMETHYLPYRIDIN-4-YL) PIPERAZIN-1-YL] PROPYLMERCAPTO} PYRIMIDIN-4-OL-FUMARATE

The fumaric acid salt of 2-{3-[4-(2-t-butyl-6-trifluoromethyl-4-pyrimidinyl)-1-piperazinyl]propylthio}-4-pyrimidinol is useful for treating disorders which respond to dopamine D3 ligands. It has higher stability at low pH and is therefore particularly suitable for oral administration in pharmaceutical compositions comprising this salt.