194163-31-0

Basic information

• Product Name: 6-CYANO-1H-INDAZOLE-3-CARBOXYLIC ACID
• Synonyms: 6-CYANO-1H-INDAZOLE-3-CARBOXYLIC ACID
• CAS NO: 194163-31-0
• Molecular Formula: C9H5N3O2
• Molecular Weight: 187.15
• Mol File: 194163-31-0.mol

Chemical Properties

• Boiling Point: 535.031 °C at 760 mmHg
• Flash Point: 277.377 °C
• Appearance: /
• Density: 1.592 g/cm³
• Storage Temp.: 2-8°C
• PKA: 2.36±0.10(Predicted)
• CAS DataBase Reference: 6-CYANO-1H-INDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CYANO-1H-INDAZOLE-3-CARBOXYLIC ACID(194163-31-0)
• EPA Substance Registry System: 6-CYANO-1H-INDAZOLE-3-CARBOXYLIC ACID(194163-31-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 194163-31-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-CYANO-1H-INDAZOLE-3-CARBOXYLIC ACID is used as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique chemical structure allows for the development of new drugs with diverse therapeutic applications.
Used in Synthesis of Indazole Derivatives:
In the field of medicinal chemistry, 6-CYANO-1H-INDAZOLE-3-CARBOXYLIC ACID is utilized as a precursor for the synthesis of indazole derivatives. These derivatives exhibit a range of biological activities, including antimicrobial, antifungal, and anticancer properties, making them valuable for the development of new therapeutic agents.
Used in Materials Science:
6-CYANO-1H-INDAZOLE-3-CARBOXYLIC ACID is also used in the field of materials science, particularly for the development of organic semiconductors and optoelectronic devices. Its unique electronic properties and structural characteristics make it a promising candidate for these applications, contributing to advancements in technology and electronics.

Upstream product

• 885279-19-6 6-cyano-1H-indazole-3-carboxylic acid ethyl ester 
• 15861-36-6 1H-Indole-6-carbonitrile 
• 882803-60-3 3-formyl-1H-indazole-6-carbonitrile 

Downstream Products

• 199609-47-7 6-Carbamimidoyl-1H-indazole-3-carboxylic acid 

Relevant articles and documents

Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-α-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors

A series of highly potent and specific fibrinogen receptor antagonists have been discovered and optimized through structural modification of the novel amidinoindole and benzofuran compounds, I and II. Systematic linker optimization afforded the amidinoben

Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists

The use of 5,6-bicyclic amidines as arginine surrogates in the design of a novel class of potent platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa) antagonists is described. The additional conformational restriction offered by the bicyclic nucleus results in 20-400-fold increases in potency compared to the freely flexible, acyclic benzamidine counterpart. The design, synthesis, structure-activity relationships (SAR), and in vitro activity of this novel class of GPIIb-IIIa antagonists are presented.