Novel 1,3- spirocyclization reaction in the photochemistry of anthranilic acid derivatives in acetonitrile
Anthranilic acid derivatives 1a-c were irradiated in acetonitrile solution to give imines (rearranged products) 2a-c in each case. In the case of 1c, a diastereomeric mixture of dl- and meso-dibenzoate derivative (dimerization product) 3c was also obtaine
3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.
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(2008/06/13)
Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines
The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quantitative C-2 epimerization.