194482-44-5

Basic information

• Product Name: Benzoic acid,3-[(1R)-3-[bis(1-methylethyl)- amino]-1-phenylpropyl]-4-hydroxy-
• Synonyms: (R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-hydroxybenzoic acid;(R)-(-)-3-(3-diisopropylamino-1-phenylpropyl)-4-hydroxybenzoic acid;(R)-3-(3-N,N-diisopropylamino-1-phenyl-propyl)-4-hydroxy-benzoic acid
• CAS NO: 194482-44-5
• Molecular Formula: C22H29NO3
• Molecular Weight: 355.477
• Mol File: 194482-44-5.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid,3-[(1R)-3-[bis(1-methylethyl)- amino]-1-phenylpropyl]-4-hydroxy- (CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid,3-[(1R)-3-[bis(1-methylethyl)- amino]-1-phenylpropyl]-4-hydroxy- (194482-44-5)
• EPA Substance Registry System: Benzoic acid,3-[(1R)-3-[bis(1-methylethyl)- amino]-1-phenylpropyl]-4-hydroxy- (194482-44-5)

Safety Data

• Hazardous Substances Data: 194482-44-5(Hazardous Substances Data)

Upstream product

• 1449220-60-3 D-(+)-menthyl 3-(3-N,N'-diisopropylamino-1(R)-phenyl-propyl)-4-hydroxy-benzoate hydrochloride 
• 1449220-62-5 racemic 3-(3-N,N'-diisopropylamino-1-phenyl-propyl)-4-hydroxy-benzoyl chloride hydrochloride 
• 173948-30-6 (E)-N,N-diisopropyl-3-phenylprop-2-en-1-amine 
• 108-18-9 diisopropylamine 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 
• 156755-24-7 methyl 3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoate 
• 156755-23-6 6-bromo-4-phenyl-3,4-dihydro-2H-chromen-2-one 
• 701906-29-8 (+)-N,N-Diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine 
• 621-82-9 Cinnamic acid 
• 106-41-2 4-bromo-phenol 
• 754159-68-7 4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid 
• 250214-37-0 (+/-)-toluene-4-sulphonic acid 3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl ester 

Downstream Products

• 207679-81-0 (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol 
• 1390644-41-3 (R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid 
• 250214-44-9 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxyl-methyl)phenyl isobutyrate 
• 286930-02-7 fesoterodine 
• 286930-03-8 fesoterodine fumarate 
• 1391913-28-2 (R)-3-(N,N'-diisopropylamino-1-phenyl-propyl)-4-isobutyryloxy-benzoic acid 
• 380636-47-5 (R)-(-)-3-(3-diisopropylamino-1-phenylpropyl)-4-hydroxybenzoic acid hydrochloride 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF OPTICALLY PURE FESOTERODINE DERIVATIVES

3,3-diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, can be produced by treating a compound of formula (II) with a chiral alcohol to yield the diastereomeric esters of formula (IV) and (IV′), which can be further transformed into a compound of formula (I), or an enantiomer, solvate or salt thereof, wherein R1 is C1-C8 alkyl; and R2 and R3, independently of one another, represent H or C1-C6 alkyl, or together form a ring of 3 to 7 members with the nitrogen to which they are bound.

PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 3,3-DIPHENYLPROPYLAMINES

The invention relates to a process for obtaining 3,3-diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, comprising treating a compound of formula (II) with a chiral alcohol to yield the diastereomeric esters of formula (IV) and (IV'), which can be further transformed into a compound of formula (I), or an enantiomer, solvate or salt thereof, wherein R1 is C1-C8 alkyl; and R2 and R3, independently of one another, represent H or C1-C6 alkyl, or together form a ring of 3 to 7 members with the nitrogen to which they are bound.

PROCESS FOR THE PREPARATION OF MUSCARINIC RECEPTOR ANTAGONIST

The present invention relates to novel and improved processes for the preparation of (r)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate represented by the following structural formula-1 and its pharmaceutically acceptable salts thereof.

PROCESS FOR PREPARATION OF 3-(2-HYDROXY-5-SUBSTITUTED PHENYL)-N-ALKYL-3-PHENYLPROPYLAMINES

A new process for preparation of 3-(2-hydroxy-5-substituted phenyl)-N,alkyl-3- phenylpropylamiηes from cinamoyl chloride via N-alky-3-phenylprop-2-en-1 -amine has been developed.

Shortened synthesis of 3,3-diarylpropylamine derivatives

The invention relates to a method for producing derivatives of 3,3-diarylpropylamines of general formula (I) and sterically highly pure, stable intermediate products, and to their use for producing pharmaceutical compositions.