194851-19-9Relevant articles and documents
INDOLE CARBOXAMIDES AS IKK2 INHIBITORS
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Page/Page column 167-168, (2008/12/04)
The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Antiinflammation agents
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Page/Page column 33-34, (2010/02/06)
Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.
Quinazoline compounds
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, (2008/06/13)
The invention concerns quinazoline compounds of the formula I STR1 wherein Q 1 is a 5- or 6-membered heteroaryl moiety and Q 1 optionally bears up to 3 substituents;wherein m is 1 or 2 and each R 1 may be a group such as hydrogen, halogeno and trifluorome