New spermine and spermidine derivatives as potent inhibitors of trypanosoma cruzi trypanothione reductase
Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (K(i) = 0.4 μM) is the most potent TR inhibitor described so far.
Bonnet, Beatrice,Soullez, David,Davioud-Charvet, Elisabeth,Landry, Valerie,Horvath, Dragos,Sergheraert, Christian
p. 1249 - 1256
(2007/10/03)
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