195073-76-8Relevant articles and documents
New spermine and spermidine derivatives as potent inhibitors of trypanosoma cruzi trypanothione reductase
Bonnet, Beatrice,Soullez, David,Davioud-Charvet, Elisabeth,Landry, Valerie,Horvath, Dragos,Sergheraert, Christian
, p. 1249 - 1256 (2007/10/03)
Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (K(i) = 0.4 μM) is the most potent TR inhibitor described so far.