195136-66-4

Basic information

• Product Name: 3-Fluoro-2,4-dimethoxyaniline
• Synonyms: 3-Fluoro-2,4-dimethoxyaniline;3-Fluoro-2,4-dimethoxyaniline 98%;3-Fluoro-2,4-dimethoxyaniline98%;2,4-Dimethoxy-3-fluoroaniline
• CAS NO: 195136-66-4
• Molecular Formula: C₈H₁₀FNO₂
• Molecular Weight: 171.1689032
• Product Categories: Amines;blocks;FluoroCompounds
• Mol File: 195136-66-4.mol

Chemical Properties

• Boiling Point: 286.249 °C at 760 mmHg
• Flash Point: 126.919 °C
• Appearance: /
• Density: 1.189 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Fluoro-2,4-dimethoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-2,4-dimethoxyaniline(195136-66-4)
• EPA Substance Registry System: 3-Fluoro-2,4-dimethoxyaniline(195136-66-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 195136-66-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
3-Fluoro-2,4-dimethoxyaniline is utilized as an intermediate in pharmaceutical research for the synthesis of new drugs. Its unique structure allows for the development of compounds with specific therapeutic properties, targeting a range of diseases and medical conditions.
Used in Organic Synthesis:
In the realm of organic synthesis, 3-Fluoro-2,4-dimethoxyaniline is employed as a key building block. Its presence in the synthesis process contributes to the formation of complex organic molecules with diverse applications.
Used in Agrochemical Production:
3-Fluoro-2,4-dimethoxyaniline is also used as an intermediate in the production of agrochemicals, where its chemical properties are leveraged to create compounds that can enhance crop protection and yield.
Used in the Production of Specialty Chemicals and Advanced Materials:
3-Fluoro-2,4-dimethoxyaniline's unique structure and properties make it a valuable component in the creation of specialty chemicals and advanced materials, which can have applications in various industries, including electronics, coatings, and plastics.

InChI:InChI=1/C8H10FNO2/c1-11-6-4-3-5(10)8(12-2)7(6)9/h3-4H,10H2,1-2H3

Upstream product

• 155020-44-3 2-fluoro-1,3-dimethoxy-4-nitrobenzene 
• 771-69-7 2,3,4-trifluoronitrobenzene 

Downstream Products

• 1401998-80-8 3-fluoro-2,4-dihydroxybenzaldehyde 
• 502483-90-1 3-fluoro-2,4-dimethoxybenzaldehyde 
• 1270166-66-9 8-fluoro-4-methylumbelliferyl 2,3,4-tri-O-acetyl-6-O-((18)O)benzoyl-β-D-(6-(18)O)-galactopyranoside 
• 905752-13-8 2-fluoro-4-iodo-1,3-dimethoxybenzene 
• 103068-40-2 2-fluoro resorcinol 
• 195136-68-6 1,3-dimethoxy-2-fluorobenzene 

Relevant articles and documents

8-FLUORO-4-ALKYLUMBELLIFERYL ALPHA-D-GLUCOPYRANOSIDE, BIOLOGICAL STERILIZATION INDICATOR INCLUDING THE SAME AND ITS USE IN A METHOD OF DETERMINING EFFICACY OF A STERILIZATION PROCESS

A self-contained biological sterilization indicator comprises: a housing; bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of an enzyme substrate; and a frangible container containing a composition, wherein the composition comprises the enzyme substrate, wherein if the frangible container is broken the composition will contact the bacterial spores to form a mixture having an initial pH in the range from 6.0 to 9.0. The enzyme substrate comprises a fluorinated 4'-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I), wherein R is an alkyl group having from 1 to 12 carbon atoms. A biological sterilization indicator comprising a kit containing isolated components comprising (i) bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of the enzyme substrate and a method of assessing efficacy of a sterilization process are also disclosed.

1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS

Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula:A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:

Turnover Is rate-limited by deglycosylation for micromonospora viridifaciens sialidase-catalyzed hydrolyses: Conformational implications for the Michaelis complex

A panel of seven isotopically substituted sialoside natural substrate analogues based on the core structure 7-(5-acetamido-3,5-dideoxy-d-glycero- α-d-galacto-non-2-ulopyranosylonic acid)-(2→6)-β-d- galactopyranosyloxy)-8-fluoro-4-methylcoumarin (1, Neu5Acα2,6GalβFMU) have been synthesized and used to probe the rate-limiting step for turnover by the M. viridifaciens sialidase. The derived kinetic isotope effects (KIEs) on kcat for the ring oxygen (18V), leaving group oxygen (18V), anomeric carbon (13V), C3-carbon (13V), C3-R deuterium (DVR), C3-S deuterium (DV S), and C3-dideuterium (D2V) are 0.986 ± 0.003, 1.003 ± 0.005, 1.021 ± 0.006, 1.001 ± 0.008, 1.029 ± 0.007, 0.891 ± 0.008, and 0.890 ± 0.006, respectively. The solvent deuterium KIE (D2OV) for the sialidase-catalyzed hydrolysis of 1 is 1.585 ± 0.004. In addition, a linear proton inventory was measured for the rate of hydrolysis, under saturating condition, as a function of n, the fraction of deuterium in the solvent. These KIEs are compatible with rate-determining cleavage of the enzymatic tyrosinyl β-sialoside intermediate. Moreover, the secondary deuterium KIEs are consistent with the accumulating Michaelis complex in which the sialosyl ring of the carbohydrate substrate is in a 6S2 skew boat conformation. These KIE measurements are also consistent with the rate-determining deglycosylation reaction occurring via an exploded transition state in which synchronous charge delocalization is occurring onto the ring oxygen atom. Finally, the proton inventory and the magnitude of the solvent KIE are consistent with deglycosylation involving general acid-catalyzed protonation of the departing tyrosine residue rather than general base-assisted attack of the nucleophilic water.

CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS

The present invention relates to compounds of formula (I) for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases, including cathepsins B, K, C, F, H, L, O, S, W and X. Of particular interest are diseases associated with Cathepsin K.

NOVEL TUBULIN POLYMERISATION INHIBITORS

The present invention relates to compounds of general formula (I) as tublin polymerisation inhibitors and methods for preparing such compounds.

Fluorinated xanthene derivatives

The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes in the physiological range of 6-8 than do non-fluorinated dyes, exhibit less quenching when conjugated to a substance, and possess additional advantages. The dyes of the invention are useful as detectable tracers and for preparing conjugates of organic and inorganic substances.

Synthesis of fluorinated fluoresceins

Several novel fluorinated fluoresceins (Oregon Green dyes) were prepared by the reaction of fluororesorcinols with phthalic anhydride and its derivatives. A novel regiospecific synthesis of fluororesorcinols was key to the successful synthesis of these new fluorophores. (Polyfluoro)- nitrobenzenes were reacted with 2 equiv of sodium methoxide followed by reduction, hydrodediazoniation, and demethylation, giving the first straightforward synthesis of 2-fluororesorcinol, 4-fluororesorcinol, 2,4- difluororesorcinol, and 2,4,5-trifluororesorcinol. These fluorinated fluoresceins have higher photostability and ionize at a lower pH (pK(a) = 3.3-6.1) than fluorescein (pK(a) = 6.5). Some of the fluorinated fluoresceins have very high quantum yields (0.85-0.97), which, in combination with their lower pK(a)s and high photostability, makes them superior fluorescent dyes for use as reporter molecules in biological systems.