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IFLAB-BB F2124-0088 is a chemical compound primarily utilized as a research tool in diverse scientific and medical disciplines, including cell biology, biochemistry, and drug discovery. Its specific properties and applications are context-dependent, tailored to the research objectives of the scientists employing it. As a versatile tool, it aids in the comprehension of biological processes and the development of novel medical treatments.

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  • 195252-56-3 Structure
  • Basic information

    1. Product Name: IFLAB-BB F2124-0088
    2. Synonyms: IFLAB-BB F2124-0088;6-CHLORO-N4-PROPYL-4,5-PYRIMIDINEDIAMINE
    3. CAS NO:195252-56-3
    4. Molecular Formula: C7H11ClN4
    5. Molecular Weight: 186.64
    6. EINECS: N/A
    7. Product Categories: Heterocycle-Pyrimidine series
    8. Mol File: 195252-56-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 340.8 °C at 760 mmHg
    3. Flash Point: 159.9 °C
    4. Appearance: /
    5. Density: 1.309 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. CAS DataBase Reference: IFLAB-BB F2124-0088(CAS DataBase Reference)
    10. NIST Chemistry Reference: IFLAB-BB F2124-0088(195252-56-3)
    11. EPA Substance Registry System: IFLAB-BB F2124-0088(195252-56-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 195252-56-3(Hazardous Substances Data)

195252-56-3 Usage

Uses

Used in Scientific Research:
IFLAB-BB F2124-0088 is used as a research tool for [application reason] in the field of [specific scientific or medical field], contributing to the advancement of knowledge and potential treatments.
Used in Cell Biology:
IFLAB-BB F2124-0088 is used as a research tool for studying cellular processes and mechanisms, aiding in the understanding of cell function and behavior.
Used in Biochemistry:
IFLAB-BB F2124-0088 is used as a research tool for investigating biochemical reactions and pathways, facilitating the discovery of new biochemical insights.
Used in Drug Discovery:
IFLAB-BB F2124-0088 is used as a research tool for identifying and testing potential drug candidates, playing a crucial role in the development of new therapeutic agents.
Depending on the specific context and research aims, IFLAB-BB F2124-0088 may have additional applications in various industries, each with its unique application reason and contribution to the field.

Check Digit Verification of cas no

The CAS Registry Mumber 195252-56-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,2,5 and 2 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 195252-56:
(8*1)+(7*9)+(6*5)+(5*2)+(4*5)+(3*2)+(2*5)+(1*6)=153
153 % 10 = 3
So 195252-56-3 is a valid CAS Registry Number.

195252-56-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-chloro-4-N-propylpyrimidine-4,5-diamine

1.2 Other means of identification

Product number -
Other names F2124-0088

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:195252-56-3 SDS

195252-56-3Relevant articles and documents

Projected Dose Optimization of Amino- And Hydroxypyrrolidine Purine PI3KδImmunomodulators

Methot, Joey L.,Zhou, Hua,McGowan, Meredeth A.,Anthony, Neville John,Christopher, Matthew,Garcia, Yudith,Achab, Abdelghani,Lipford, Kathryn,Trotter, Benjamin Wesley,Altman, Michael D.,Fradera, Xavier,Lesburg, Charles A.,Li, Chaomin,Alves, Stephen,Chappell, Craig P.,Jain, Renu,Mangado, Ruban,Pinheiro, Elaine,Williams, Sybill M. G.,Goldenblatt, Peter,Hill, Armetta,Shaffer, Lynsey,Chen, Dapeng,Tong, Vincent,McLeod, Robbie L.,Lee, Hyun-Hee,Yu, Hongshi,Shah, Sanjiv,Katz, Jason D.

, p. 5137 - 5156 (2021/05/04)

The approvals of idelalisib and duvelisib have validated PI3Kδinhibitors for the treatment for hematological malignancies driven by the PI3K/AKT pathway. Our program led to the identification of structurally distinct heterocycloalkyl purine inhibitors wit

New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases

Lambertucci, Catia,Marucci, Gabriella,Dal Ben, Diego,Buccioni, Michela,Spinaci, Andrea,Kachler, Sonja,Klotz, Karl-Norbert,Volpini, Rosaria

, p. 199 - 213 (2018/04/05)

The synthesis of 9-alkyl substituted adenine derivatives presenting aromatic groups and cycloalkyl rings in 8- and N6-position, respectively, is reported. The compounds were tested with radioligand binding studies showing, in some cases, a low

A One-Pot Synthesis of Highly Functionalized Purines

Zelli, Renaud,Zeinyeh, Wa?l,Haudecoeur, Romain,Alliot, Julien,Boucherle, Benjamin,Callebaut, Isabelle,Décout, Jean-Luc

supporting information, p. 6360 - 6363 (2017/12/08)

Highly substituted purines were synthesized in good to high yields through a one-pot straightforward metal-free scalable method, using the Traube synthesis adapted to Vilsmeier-type reagents. From 5-amino-4-chloropyrimidines, new 9-aryl-substituted chloropurines and intermediates for peptide nucleic acid synthesis were prepared. Variant procedures allowing a rapid synthesis of ribonucleosides and 7-benzylpurine from 5-amidino-6-aminopyrimidines are also reported to illustrate the high potential of this versatile toolbox. This route appears to be particularly interesting in the field of nucleic acids for a direct and rapid access to various new 8-alkylpurine nucleosides.

PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA

-

Page/Page column 175, (2014/06/11)

The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflamation, asthma, COPD and cancer.

An efficient one-pot synthesis of 6-alkoxy-8,9-dialkylpurines via reaction of 5-amino-4-chloro-6-alkylaminopyrimidines with N,N-dimethylalkaneamides and alkoxide ions

Baraldi, Pier Giovanni,Broceta, Asier Unciti,Infantas, Maria Josè Pineda De Las,Mochun, Juan Josè Dìaz,Espinosa, Antonio,Romagnoli, Romeo

, p. 7607 - 7611 (2007/10/03)

The synthesis of a number of new 6-alkoxy-8,9-(disubstituted)purines has been accomplished by the cyclization of the corresponding intermediate 5-amino-4-chloro-6-(alkylamino)pyrimidines promoted by alkoxides and various N,N-dimethyl amides, where the latter act as solvent-reagents. By this three-component condensation reaction we are able to introduce an alkyl group in the 8 position of the purine ring with the concomitant nucleophilic replacement of the 6-chloro group with an alkoxy moiety.

6-(alkylamino)-9-alkylpurines. A new class of potential antipsychotic agents

Kelley, James L.,Morris Bullock,Krochmal, Mark P.,McLean, Ed W.,Linn, James A.,Durcan, Micheal J.,Cooper, Barrett R.

, p. 3207 - 3216 (2007/10/03)

A series of 6-(alkylamino)-9-alkylpurines was synthesized and evaluated for the property of antagonizing the behavioral effects in animals of the dopamine agonist apomorphine. This model for identifying potential antipsychotic agents is based on the hypothesis that agents that antagonize apomorphine-induced aggressive behavior in rats and apomorphine-induced climbing in mice, but that do not block stereotyped behavior, could have an antipsychotic effect in humans without producing extrapyramidal side effects. The antiaggressive-behavior activity of lead compound 1 (6-(dimethylamino)- 9-(3-phenylalaninamidobenzyl)-9H-purine) was improved 48-fold with 6- (cyclopropylamino)-9-(cyclopropylmethyl)-2-(trifluoromethyl)-9H-purine (80) (po ED50 of 2 mg/kg), which was obtained through an iterative sequence of structure-activity relationship studies that encompassed evaluation of the effects of structure variations at the purine 9-, 6-, and 2-positions. Potency was enhanced with a 9-cyclopropyl group, the duration of action was improved with the 6-(cyclopropylamino) substituent, potency was further enhanced with an N-formyl prodrug, and an agent with reduced cardiovascular effect emerged with the 2-trifluoromethyl purine 80. This potential antipsychotic agent was not developed further due to undesirable effects on the stomach.

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