89981-46-4

Basic information

• Product Name: 6-Chloro-9-propyl-9H-purine
• Synonyms: 6-Chloro-9-propyl-9H-purine
• CAS NO: 89981-46-4
• Molecular Formula: C₈H₉ClN₄
• Molecular Weight: 196.63686
• Mol File: 89981-46-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Chloro-9-propyl-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-9-propyl-9H-purine(89981-46-4)
• EPA Substance Registry System: 6-Chloro-9-propyl-9H-purine(89981-46-4)

Safety Data

• Hazardous Substances Data: 89981-46-4(Hazardous Substances Data)

Upstream product

• 3724-43-4 Vilsmeier reagent 
• 195252-56-3 4,5-diamino-6-chloro-N⁴-propylpyrimidine 
• 87-42-3 6-chloropurine 
• 106-94-5 propyl bromide 
• 107-10-8 propylamine 
• 5413-85-4 5-amino-4,6-dichloropyridimine 
• 107-08-4 1-iodo-propane 
• 707-98-2 9-propyladenine 
• 64-19-7 acetic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 87-42-3 6-chloro-7H-purine 

Downstream Products

• 42240-62-0 N-benzyl-9-propyl-9H-purin-6-amine 
• 1356160-66-1 6-(benzylthio)-9-propyl-9H-purine 

Relevant articles and documents

Synthesis of novel selenotetrazole purine derivatives and their potential chemotherapeutic activities

The development of novel chemotherapeutic agents is indispensable to improve cancer treatment. One of the conventional approaches toward the synthesis of anticancer agents is the design of a compound whose structure is similar to purines found in DNA. In this study, a series of novel artificial purine nucleosides bearing selenotetrazole pharmacophore, 4a–4h, were synthesized. In order to get preliminary information about their cytotoxic activities, the interaction of compounds with DNA was investigated by UV titration and agarose gel electrophoresis and transcription inhibition studies were performed. The cytotoxic effects of the compounds against B16 melanoma, OV90 ovarian cancer, JM1 lymphoma cell lines, and PHA-induced peripheral blood lymphocytes were also investigated. In cell assay studies, the effects of the compounds on synthesis and mitosis stage of cell cycle were compared by flow cytometry. Although none of the compounds synthesized interacted with DNA and exhibited transcription inhibition, all of them significantly inhibited DNA synthesis phase and showed cytotoxic activity on cancer and proliferating cells. [Figure not available: see fulltext.]

METHOD FOR SYNTHESIZING DIVERSELY SUBSTITUTED PURINES

The present invention relates to a method for synthesizing diversely substituted purines starting from a pyrimidine. Formula (I). The method comprises the formation of an amidine group on the pyrimidine by implementing a Vilsmeier type reagent, the functi

New substituted 9-propyladenine derivatives as A2A adenosine receptor antagonists

A new series of 9-propyladenines bearing a phenylalkylamino group in the 2-position or a phenylalkyl chain in the N6-position, and further substituted with a bromine atom or a 2-furyl ring in the 8-position, were synthesized and tested at human