A modular approach to cyclic tetrapeptides related to histone deacetylase inhibition: Synthesis of epi-microsporin A
A short new route to the unusual amino acid component (S)-2-amino-8-oxodecanoic acid (Aoda) of some important HDAC inhibitors has been developed using cross metathesis reaction as the key step. An extension of the study employing grafting of a macrocyclic scaffold through cross metathesis has proved to be highly efficient for the synthesis of an isomer of the cyclic tetrapeptide HDAC inhibitor microsporin.
Mukherjee, Jyoti Prasad,Sil, Suman,Chattopadhyay, Shital K.