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8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

    Cas No: 195532-12-8

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  • 3-Quinolinecarboxylicacid,8-cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-

    Cas No: 195532-12-8

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  • 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

    Cas No: 195532-12-8

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  • 1 Kilogram

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  • Xi'an HDM Biotech Co., Ltd.
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  • 195532-12-8 Structure
  • Basic information

    1. Product Name: 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
    2. Synonyms: 195532-12-8; pradofloxacin
    3. CAS NO:195532-12-8
    4. Molecular Formula: C21H21FN4O3
    5. Molecular Weight: 396.4148
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 195532-12-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 664.525°C at 760 mmHg
    3. Flash Point: 355.692°C
    4. Appearance: N/A
    5. Density: 1.504g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.691
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
    11. NIST Chemistry Reference: 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(195532-12-8)
    12. EPA Substance Registry System: 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(195532-12-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 195532-12-8(Hazardous Substances Data)

195532-12-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 195532-12-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,5,3 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 195532-12:
(8*1)+(7*9)+(6*5)+(5*5)+(4*3)+(3*2)+(2*1)+(1*2)=148
148 % 10 = 8
So 195532-12-8 is a valid CAS Registry Number.

195532-12-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-8-cyano-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names 8-Cyano-1-cyclopropyl-6-fluoro-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:195532-12-8 SDS

195532-12-8Relevant articles and documents

Synthesis method of pradofloxacin

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Paragraph 0055; 0056; 0059-0064, (2018/05/16)

The invention relates to a synthesis method of pradofloxacin. According to the method, a cheap and easy-to-obtain compound is taken as a raw material and subjected to chlorination, acylation, nucleophilic substitution, cyclization, hydrolysis and alkylation reactions, and the target product, namely, pradofloxacin, is obtained. The nucleophilic substitution target product beta-substituted amino-alpha-substituted benzoyl acrylate compound has good quality and has the purity of 98% or above and the yield of 80%-90%, and the yield is increased by 10% or above as compared with that in the prior art; the provided ester hydrolysis method and product quality are good, and the reaction yield reaches 93%-98%; organic base is used for replacing conventional inorganic base to serve as a cyclization reaction catalyst, the operation is simple, no pollution is caused, and the cost is substantially reduced; halogenated hydrocarbon is taken as an alkylation solvent, the reaction temperature is the roomtemperature, the reaction is mild and easy to operate, fewer impurities are produced in the alkylation reaction at the temperature of 20-40 DEG C as compared with those produced in the alkylation reaction at the high temperature in the prior art, the yield is high, halogenated hydrocarbon solvents are easy to recycle and reuse, pollution is greatly reduced, and the synthesis method is environmentally friendly.

PROCESS FOR PREPARING PRADOFLOXACIN

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Page/Page column 2, (2009/12/28)

The invention relates to an improved process for preparing pradofloxacin, in which the substituent in the 7 position is introduced by nucleophilic substitution in an N-methylpyrrolidone-ethanol solvent mixture.

Crystal modification B of 8-cyano-1-cyclopropyl-7-(1S,6S-2, 8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

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Page column 4, (2008/06/13)

The present invention relates to a defined crystal modification of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of the formula (I), to processes for its preparation and to its use in pharmaceutical preparations. The crystal modification can be distinguished from other crystal modifications of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of the formula (I) by its characteristic X-ray powder diffractogram and its differential thermodiagram (see description).

Crystal modification C of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihyro-4-oxo-3-quinoline carboxylic

-

Page/Page column 3, (2008/06/13)

The present invention relates to a defined crystal modification of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of the formula (1), to processes for its preparation and to its use in pharmaceutical preparations. The crystal modification can be distinguished from other crystal modifications of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of the formula (1) by its characteristic X-ray powder diffractogram and its differential thermodiagram (see description).

Optionally substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives

-

, (2008/06/13)

Intermediates useful in the preparation of 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]nonan-8-yl-6-fluorol,4-dihydro-4-oxo-3-quinolinecarboxylic acids of the following structures are claimed.

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