195532-67-3Relevant academic research and scientific papers
Synthesis method of pradofloxacin
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Paragraph 0068; 0069, (2018/05/16)
The invention relates to a synthesis method of pradofloxacin. According to the method, a cheap and easy-to-obtain compound is taken as a raw material and subjected to chlorination, acylation, nucleophilic substitution, cyclization, hydrolysis and alkylation reactions, and the target product, namely, pradofloxacin, is obtained. The nucleophilic substitution target product beta-substituted amino-alpha-substituted benzoyl acrylate compound has good quality and has the purity of 98% or above and the yield of 80%-90%, and the yield is increased by 10% or above as compared with that in the prior art; the provided ester hydrolysis method and product quality are good, and the reaction yield reaches 93%-98%; organic base is used for replacing conventional inorganic base to serve as a cyclization reaction catalyst, the operation is simple, no pollution is caused, and the cost is substantially reduced; halogenated hydrocarbon is taken as an alkylation solvent, the reaction temperature is the roomtemperature, the reaction is mild and easy to operate, fewer impurities are produced in the alkylation reaction at the temperature of 20-40 DEG C as compared with those produced in the alkylation reaction at the high temperature in the prior art, the yield is high, halogenated hydrocarbon solvents are easy to recycle and reuse, pollution is greatly reduced, and the synthesis method is environmentally friendly.
Use of 7-(2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-quinolone carboxylic acid and naphthyridon carboxylic acid derivatives for the treatment of Helicobacter pylori infections and associated gastroduodenal diseases
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, (2008/06/13)
PCT No. PCT/EP97/06781 Sec. 371 Date Jun. 14, 1999 Sec. 102(e) Date Jun. 14, 1999 PCT Filed Dec. 4, 1997 PCT Pub. No. WO98/26779 PCT Pub. Date Jun. 25, 1998The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives which a
