Chlorination of nucleosides by N-chlorodiisopropylamine and triphenylphosphine
The combination of N-chlorodiisopropylamine and triphenylphosphine (1) was exploited as a new method for chlorination of the hydroxyl group on the nucleosides. A possible mechanism involving an oxyphosphonium intermediate 2a and a phosphorane intermediate 2b was proposed based on the results from 31P NMR spectrum.
Zhou, Yi-Sui,Miao,Zhao, Yu-Fen
p. 671 - 673
(2007/10/03)
Nucleic acid related compounds. 66. Improved synthese of 5'-chloro-5'-deoxy- and 5'-S-aryl(or alkyl)-5'-thionucleosides
-
Robins,Hansske,Wnuk,Kanai
p. 1468 - 1474
(2007/10/02)
9-(4-METHOXYPHENYL)XANTHEN-9-THIOL: A USEFUL REAGENT FOR THE PREPARATION OF THIOLS
Treatment of 5'-chloro-5'-deoxynucleosides (5) with the conjugate base of 9-(4-methoxyphenyl)xanthen-9-thiol (3b), followed by acid-promoted removal of the 5'-S- group in the presence of pyrrole gives the corresponding 5'-deoxy-5'-mercaptonucleosides (7) in good yields.
Marriott, Jonathan H.,Mottahedeh, Mina,Reese, Colin B.
p. 7485 - 7488
(2007/10/02)
Halo sugar nucleosides. 3. Reactions for the chlorination and bromination of nucleoside hydroxyl groups.
-
Verheyden,Moffatt
p. 2289 - 2299
(2007/10/05)
More Articles about upstream products of 19556-54-8