- Carboranes. V. Silicon derivatives
-
Compounds containing silicon and carborane groups were prepared by (1) reaction of hydroxymethylcarboranes with alkylchlorosilanes, (2) reaction of alkynylsilanes with bis(acetonitrile)decaborane, (3) addition of silanes to alkenyl carboranes, and (4) rea
- Schwartz, Nelson N.,O'Brien, Eugene,Karlan, Sidney,Fein, Marvin M.,Green, Joseph
-
-
Read Online
- 11B NMR Probes of Copper(II): Finding and Implications of the Cu2+-Promoted Decomposition of ortho-Carborane Derivatives
-
The development of noninvasive methodologies for the detection of d-block metal ions such as copper (Cu2+), zinc (Zn2+), and manganese (Mn2+) is important for understanding their biological roles and relationship with diseases. We have been interested in the use of 11B NMR probes for the detection of d-block metal ions, because 11B is an ultratrace element in living systems. o-Carboranes, which consist of ten boron and two carbon atoms, have been applied to numerous drugs and biological active agents. In this work, we found that the o-carborane-pendant cyclens (L3-L5) (cyclen = 1,4,7,10-tetraazacyclododecane) are decomposed in the presence of Mn2+ or Cu2+ in aqueous solution at neutral pH, accompanied by the release of 4-9 equiv. of B(OH)3. Furthermore, it was found that o-carborane derivatives that contain hydroxyl groups instead of a cyclen unit also undergo decomposition in the presence of Cu2+ and the corresponding complexes such as Cu(bpy) to afford 10 equiv. of B(OH)3, as confirmed by 11B NMR spectroscopic analysis and an azomethine-H assay. These reactions are applied to 11B MRI (magnetic resonance imaging) probes for Cu2+.
- Tanaka, Tomohiro,Nishiura, Yukiko,Araki, Rikita,Saido, Takaomi,Abe, Ryo,Aoki, Shin
-
p. 1819 - 1834
(2016/05/02)
-
- Carboranes. II. The preparation of 1- and 1,2-substituted carboranes
-
The broad applicability o the conversion of mono- and disubstituted acetylenes to carboranes by treatment with decaborane and Lewis bases is demonstrated. The resultant carboranes may then be treated as typically organic, covalent products and, by usual s
- Fein, Marvin M.,Grafstein, Daniel,Paustian, John E.,Bobinski, Jack,Lichstein, Bernard M.,Mayes, Nathan,Schwartz, Nelson N.,Cohen, Murray S.
-
p. 1115 - 1119
(2008/10/08)
-
- A new series of organoboranes. III. Some reactions of 1,2-dicarbaclovododecaborane(12) and its derivatives
-
The general participation of carborane and its derivatives in standard organic chemical transformations has been established. Reactions of carborane and some functionally substituted derivatives are described. Differences in the reactivity of the hydrogen atoms attached to carbon atoms of carborane from those attached to the boron atoms have been demonstrated.
- Heying,Ager Jr.,Clark,Alexander,Papetti,Reid,Trotz
-
p. 1097 - 1105
(2008/10/08)
-