196500-09-1

Basic information

• Product Name: 2-METHYL-3-NITROBENZYL METHANESULFONATE
• Synonyms: 2-METHYL-3-NITROBENZYL METHANESULFONATE
• CAS NO: 196500-09-1
• Molecular Formula: C₉H₁₁NO₅S
• Molecular Weight: 245.25
• Mol File: 196500-09-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-METHYL-3-NITROBENZYL METHANESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-3-NITROBENZYL METHANESULFONATE(196500-09-1)
• EPA Substance Registry System: 2-METHYL-3-NITROBENZYL METHANESULFONATE(196500-09-1)

Safety Data

• Hazardous Substances Data: 196500-09-1(Hazardous Substances Data)

Usage

Uses

2-Methyl-3-nitrobenzyl Mesylate is used in preparation of Ropinirole Hydrochloride.

Upstream product

• 23876-13-3 (2-methyl-3-nitrophenyl)methanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 179626-03-0 2-Methyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenylamine 
• 215930-27-1 2-Amino-N-methyl-N-[2-methyl-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-acetamide 
• 23876-14-4 3-nitro-2-methylphenylacetonitrile 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE

A process for the preparation of 4-[2-(Di-n-propylamino) ethyl]-2,3-dihydro-1 H-indol-2-one of formula (I) and its pharmaceutically acceptable salts, solvates Formaula I involving new intermediates of compound of formula (A) and (B) wherein R represents (i) a halogen atom selected from fluorine, chlorine atom, bromine atom and iodine atom; (ii) lower alkanesulfonyloxy group selected from methanesulfonyloxy, ethanesulfonyloxy, isopropanesulfonyloxy, propanesulfonyloxy, butanesulfonyloxy, tert-butanesulfonyloxy, pentanesulfonyloxy, hexanesulfonyloxy; (iii) substituted or unsubstantiated arylsulfonyloxy group selected from phenylsulfonyloxy, 4-methylphenylsulfonyloxy, 2-methylphenylsulfonyloxy, 4- nitrophenylsulfonyloxy, 4- methoxyphenylsulfonyloxy, 3-chlorophenylsulfonyloxy; (iv) arylalkylsulfonyloxy group selected from benzylsulfonyloxy, 2- phenylethylsulfonyloxy, 4-phenylbutylsulfonyloxy, 4- methylbenzylsulfonyloxy, 2- methylbenzylsulfonyloxy, 4- nitrobenzylsulfonyloxy, 4-methoxybenzylsulfonyloxy, 3- chlorobenzylsulfonyloxy.

New indazole and indolone derivatives and their use pharmaceuticals

The present invention provides for compounds of formula (I), which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 4. Discovery of novel frameworks mimicking the active conformation

In recent articles we reported the identification of a series of 8- [[2,6-dichloro-3-[N-methyl-N-[(E)- (substituted)acryloylglycyl]amino]benzyl]oxy]-2-methylimidazo[1,2- a]pyridines as the first orally active non-peptide bradykinin (BK) B2 rece