19655-46-0

Basic information

• Product Name: 8-chloro-6-methylquinoline
• Synonyms: 8-chloro-6-methylquinoline;6-Methyl-8-chloroquinoline
• CAS NO: 19655-46-0
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 178
• EINECS: -0
• Mol File: 19655-46-0.mol

Chemical Properties

• Melting Point: 62.5 °C
• Boiling Point: 294.7±20.0 °C(Predicted)
• Appearance: /
• Density: 1.225
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.56±0.20(Predicted)
• CAS DataBase Reference: 8-chloro-6-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-6-methylquinoline(19655-46-0)
• EPA Substance Registry System: 8-chloro-6-methylquinoline(19655-46-0)

Safety Data

• Hazardous Substances Data: 19655-46-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-chloro-6-methylquinoline is used as a building block for the synthesis of various pharmaceuticals due to its potential biological activities, including antiviral and antimicrobial properties. It plays a crucial role in drug development, contributing to the creation of new medications with improved efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical sector, 8-chloro-6-methylquinoline serves as a key component in the synthesis of various agrochemicals. Its incorporation aids in the development of effective pesticides, herbicides, and other agricultural chemicals that protect crops and enhance agricultural productivity.
Used in Chemical Production:
8-chloro-6-methylquinoline is utilized in the production of dyes and pigments, adding color and vibrancy to various products. Its presence in these compounds contributes to their stability, brightness, and resistance to fading, making it an essential component in the dye and pigment industry.
Used in Specialty Chemicals:
8-chloro-6-methylquinoline also finds application in the production of specialty chemicals, where its unique properties are harnessed to create high-performance materials for specific industrial applications. Its versatility and reactivity make it a valuable asset in the development of advanced chemical products.

Upstream product

• 99-99-0 1-methyl-4-nitrobenzene 
• 56-81-5 glycerol 
• 615-65-6 2-chloro-4-methyl-benzenamine 
• 7647-01-0 hydrogenchloride 
• 107-18-6 allyl alcohol 
• 176097-89-5 8-chloro-6-methyl-1,2,3,4-tetrahydroquinoline 

Downstream Products

• 1071675-48-3 2,8-dichloro-6-methyl-[5]quinolylamine 

Relevant articles and documents

From Anilines to Quinolines: Iodide- and Silver-Mediated Aerobic Double C?H Oxidative Annulation–Aromatization

Quinoline synthesis from easily accessible raw materials such as anilines is a valuable and meaningful task. Herein, we communicate an iodide- and silver-mediated C?H/C?H oxidative annulation–aromatization between anilines and allyl alcohols. This protocol provides a direct route to the synthesis of quinoline derivatives from inexpensive commodities. Various kinds of anilines, even heterocyclic anilines, were shown to be workable substrates, generating the corresponding multi-substituted quinolines in good yields.

Novel routes to indoles, indolines, quinolines and tetrahydroquinolines from N-(cyclohexylidene)amines

Cyclohexanones have been converted into a variety of bicyclic azaheterocycles of different oxidation level via a sequence of reactions involving (a) imination, (b) α-alkylation with N,N-disilyl-protected ω-bromoamines, (c) transimination, (d) α-chlorination of the resulting bicyclic imines and (e) dehydrochlorination and/or dehydrogenation. Appropriate choice of the reaction conditions selectively led to reactions to indoles, 7-chloroindoles, 7-chloroindolines, 4,5,6,7-tetrahydroindoles, 8-chloro-1,2,3,4-tetrahydroquinolines, 8-chloroquinolines or quinolines.