19658-76-5

Basic information

• Product Name: 1-nitroisoquinoline
• Synonyms: 1-nitroisoquinoline
• CAS NO: 19658-76-5
• Molecular Formula: C₉H₆N₂O₂
• Molecular Weight: 174.15614
• Mol File: 19658-76-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-nitroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-nitroisoquinoline(19658-76-5)
• EPA Substance Registry System: 1-nitroisoquinoline(19658-76-5)

Safety Data

• Hazardous Substances Data: 19658-76-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry Research:
1-nitroisoquinoline is used as a research compound for studying its chemical properties and reactivity. Its ability to undergo various chemical transformations makes it a valuable tool in organic chemistry.
Used in Pharmaceutical Synthesis:
1-nitroisoquinoline is used as a building block in the synthesis of various pharmaceuticals. Its versatility as a starting material contributes to the development of new and effective drugs.
Used in Agrochemical Synthesis:
1-nitroisoquinoline is also used in the synthesis of agrochemicals, such as pesticides and herbicides. Its reactivity and potential to form various compounds make it a useful component in the development of agricultural products.
Used in Anti-cancer Applications:
1-nitroisoquinoline has been studied for its potential as an anti-cancer agent. Its biological activities have shown promise in targeting and inhibiting the growth of cancer cells, making it a candidate for further research and development in cancer treatment.
Used in Anti-microbial Applications:
1-nitroisoquinoline has demonstrated potential as an anti-microbial agent. Its ability to target and inhibit the growth of microorganisms, such as bacteria and fungi, makes it a candidate for further exploration in the development of antimicrobial treatments and products.

Upstream product

• 79933-06-5 1-nitrosoisoquinoline 
• 119-65-3 isoquinoline 
• 1532-84-9 isoquinolin-1-ylamine 
• 79917-36-5 1-isoquinolyl-2-methyl-2-thia-1-azaprop-1-ene 

Downstream Products

• 1532-84-9 isoquinolin-1-ylamine 
• 46000-11-7 N-methylisoquinolin 1-amine 
• 209416-32-0 4-amino-1-(2,4,6-trimethylphenyl)-isoquinoline 

Relevant articles and documents

DMSO-Ac2O promoted nitration of isoquinolines. One-step synthesis of 1-nitroisoquinolines under mild conditions

1-Nitroisoquinolines were directly prepared from the corresponding isoquinolines with potassium nitrite and acetic anhydride in DMSO in good yields.

Method for nitrating aromatic compound by using nitrate under the action of auxiliary agent

The invention discloses a method for nitrating an aromatic compound by using a nitrate under the action of an auxiliary agent, and provides an aromatic nitro compound preparation method, which comprises: in the presence of an external action and an auxiliary agent, carrying out a nitrating reaction on an aromatic compound and a metal nitrate or a hydrate thereof to obtain the aromatic nitro compound, wherein the external action can cause the physical and/or chemical property change of a substance, the auxiliary agent is a substance having water absorbing ability, the external action can be mechanical force or heating, and the mechanical force can be any one selected from compression, shearing, impacting, friction, stretching, bending and vibration. According to the present invention, the method does not require any solvents so as to avoid the generation of the waste liquid; the acidic substance is not used, such that the treatment is simple after the reaction is completed, and the equipment is not damaged; the added auxiliary agent can be theoretically recycled; and the method has extremely high conversion rate and extremely high selectivity, and can be used for the nitration of conventional aromatic compounds.

Mechanical force under the action of the nitration of aromatic compounds of nitrate method (by machine translation)

The invention discloses a mechanical force under the action of the nitration of aromatic compounds of nitrate method. The invention provides a method for preparing aromatic nitro compounds, comprising the following steps: under the action of mechanical force, aromatic compound with a metal nitrate or its hydrate by the nitration reaction, to obtain the aromatic nitro compound; the mechanical fastener is machinery offers can cause material physical and/or chemical nature of the change of the external force. The mechanical force can be compression, shear, impact, friction, tensile, bending and vibration of any kind. The invention has the following advantages: without the use of any solvent, thereby avoiding the waste liquid produced; and without the use of the acidic substance, the reaction is complete after treatment is simple, without any damage to the apparatus; a very high conversion and selectivity, can be applied to the nitration of conventional aromatic compound. (by machine translation)

Isoquinolinamine and phthalazinamine derivatives: corticotropin-releasing factor receptor CRF1 specific ligands

Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF1 receptors that are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety. The compounds have the formula or the pharmaceutically acceptable salts thereof wherein Ar, R1, R2, R3, R4 and W are various organic and inorganic substituents.

Conversion of a Primary Amino Group into a Nitroso Group. Synthesis of Nitroso-Substituted Heterocycles

2-Aminopyridine, 2-amino-4-methylpyridine, 1-aminoisoquinoline, 2-aminopyrimidine, and 2-aminopyrazine have been converted to the corresponding nitroso compounds by reaction with dimethyl sulfide and N-chlorosuccinimide, deprotonation of the resulting sul