46000-11-7

Usage

Derived from

isoquinoline (a heterocyclic aromatic organic compound)

Physical form

yellow to brown solid

Melting point

104-108°C

Usage

in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds

Potential applications

in the pharmaceutical industry as a synthetic intermediate and as a starting material for the synthesis of various drugs and biologically active compounds due to its structural and reactivity properties.

Upstream product

• 19658-76-5 1-nitro-isoquinoline 
• 74-89-5 methylamine 
• 1532-84-9 isoquinolin-1-ylamine 
• 74-88-4 methyl iodide 
• 19493-44-8 1-chloroisoquinoline 
• 1198-30-7 1-isoquinolinecarbonitrile 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 19689-95-3 N-methyl-O-acetylhydroxylamine hydrochloride 
• 1721-93-3 1-methylisoquinoline 

Relevant academic research and scientific papers

Heteroarylation method of amine

The invention discloses a heteroarylation method of amine, and the method comprises the following steps of: mixing an amine compound, heteroaromatic hydrocarbon, a photocatalyst and an organic solventto obtain a solution A; and in an inert gas atmosphere, irradiating the solution A with visible light, and carrying out reaction to obtain a heteroarylated product of amine. According to the method,under mild conditions, free radical coupling of amine compounds and heteroaromatic compounds is efficiently achieved through visible light irradiation, and various heteroarylamines are synthesized. The method has good functional group compatibility and high regioselectivity, can be further applied to later modification of bioactive molecules, and shows a good industrial application prospect.

Novel sanguinarine bionic analogue and preparation method thereof

The invention belongs to the field of bionic drugs, and particularly discloses a novel sanguinarine bionic analogue and a preparation method thereof. The novel sanguinarine bionic analogue is 1-substituted-2, 3-dihydroimidazo [2, 1-a] isoquinoline salt. Compared with the prior art, the sanguinarine bionic analogue, namely, the 1-substituted-2, 3-dihydroimidazo [2, 1-a] isoquinoline salt, capable of realizing structural interconversion, is designed by taking a natural active product sanguinarine as a template and adopting a structural bionic simulation strategy on the premise of ensuring active key factors according to a molecular structure similarity principle. The sanguinarine bionic analogue prepared by the invention has a certain inhibition effect on bacteria, and has a certain effect of inhibiting tumor cell proliferation.

Metal-free, redox-neutral, site-selective access to heteroarylamine via direct radical?radical cross-coupling powered by visible light photocatalysis

Transition-metal-catalyzed C?N bond-forming reactions have emerged as fundamental and powerful tools to construct arylamines, a common structure found in drug agents, natural products, and fine chemicals. Reported herein is an alternative access to heteroarylamine via radical?radical cross-coupling pathway, powered by visible light catalysis without any aid of external oxidant and reductant. Only by visible light irradiation of a photocatalyst, such as a metal-free photocatalyst, does the cascade single-electron transfer event for amines and heteroaryl nitriles occur, demonstrated by steady-state and transient spectroscopic studies, resulting in an amine radical cation and aryl radical anion in situ for C?N bond formation. The metal-free and redox economic nature, high efficiency, and site-selectivity of C?N cross-coupling of a range of available amines, hydroxylamines, and hydrazines with heteroaryl nitriles make this protocol promising in both academic and industrial settings.

Iridium- and rhodium-catalyzed dehydrogenative silylations of C(sp 3) - H bonds adjacent to a nitrogen atom using hydrosilanes

Now that is just silylated: In the presence of iridium or rhodium catalysts, C(sp3) - H bonds adjacent to a nitrogen atom were silylated by the aid of a pyridine-directing group. In iridium catalysis, a hydrogen-trapping reagent such as norbornene or tert-butylethylene, which is usually required in late transition-metal-catalyzed dehydrogenative coupling reactions, was not required. In rhodium catalysis, however, 1 equivalent of COD (1,5-cyclooctadiene) was necessary to induce higher conversion. Copyright

NON-CYCLOPENTADIENYL-BASED CHROMIUM CATALYSTS FOR OLEFIN POLYMERIZATION

Provided is a non-cyclopentadienyl-based chromium-ligand complex, preferably a chromium-ligand complex of formula (J): LCr(RA)m(D)k (J), wherein L is a non-Cp monoanionic ligand; Cr (chromium) is in a formal oxidation stat

Amination of Some Nitroisoquinolines with Liquid Methylamine/Potassium Permanganate

5-Nitro-, 3-methyl-5-nitro-, 5,7-dinitro-, 5-chloro-8-nitro- and 8-chloro-5-nitroisoquinoline (1a-e) as well as 5-nitroisoquinoline N-oxide (1f) are aminated with a liquid methylamine solution of potassium permanganate (LMA/PP) to the corresponding mono- or mono- and bis(methylamino)-substituted nitro compounds 2 (a-m). 1-Nitroisoquinoline (1g) is aminated with LMA/PP to 1-(methylamino)isoquinoline (2n).Quantum-chemical calculations for some mononitroisoquinolines suggest that, in general, the experimentally observed regioselectivity of the amination is controlled by an interaction of frontal molecular orbitals (FMO) of the reagents. - Key Words: Methylaminations / Calculations, FMO / Isoquinolines / Aminations / Nitro compounds