19690-37-0

Basic information

• Product Name: ethane methanesulfonate
• Synonyms: ethane methanesulfonate;Methanesulfonic acid 2-hydoxyethyl;Methanesulfonic acid 2-hydroxyethyl ester
• CAS NO: 19690-37-0
• Molecular Formula: C₃H₈O₄S
• Molecular Weight: 140.16
• Mol File: 19690-37-0.mol

Chemical Properties

• Boiling Point: 323.9°Cat760mmHg
• Flash Point: 149.7°C
• Appearance: /
• Density: 1.361g/cm³
• Vapor Pressure: 1.99E-05mmHg at 25°C
• Refractive Index: 1.456
• CAS DataBase Reference: ethane methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: ethane methanesulfonate(19690-37-0)
• EPA Substance Registry System: ethane methanesulfonate(19690-37-0)

Safety Data

• Hazardous Substances Data: 19690-37-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C3H8O4S/c1-8(5,6)7-3-2-4/h4H,2-3H2,1H3

Upstream product

• 75-21-8 oxirane 
• 65411-49-6 tetrabutylammonium methanesulfonate 
• 107-21-1 ethylene glycol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1190601-01-4 C₂₃H₂₅NO₅S 

Relevant articles and documents

Synthesis and biological evaluation of a triazole-based library of pyrido[2,3-d]pyrimidines as FGFR3 tyrosine kinase inhibitors

A library of pyrido[2,3-d]pyrimidines was designed as inhibitors of FGFR3 tyrosine kinase allowing possible interactions with an unexploited region of the ATP binding-site. This library was built-up with an efficient step of click-chemistry giving easy access to triazole-based compounds bearing a large panel of substituents. Among the 27 analogues synthesized, more than half exhibited 55-89% inhibition of in vitro FGFR3 kinase activity at 2 μM and one (19g) was able to inhibit auto-phosphorylation of mutant FGFR3-K650M in transfected HEK cells.

Allosteric functional switch of neurokinin A-mediated signaling at the neurokinin NK2 receptor: Structural exploration

The neurokinin NK2 receptor is known to pre-exist in equilibrium between at least three states: restinginactive, calcium-triggering, and cAMP-producing. Its endogeneous ligand, NKA, mainly induces the calcium response. Using a FRET-based assay, we have previously discovered an allosteric modulator of the NK2 receptor that has the unique ability to discriminate among the two signaling pathways: calcium-signaling is not affected while cAMP signaling is significantly decreased. A series of compounds have been prepared and studied in order to better understand the structural determinants of this allosteric functional switch of a GPCR. Most of them display the same allosteric profile, with smooth pharmacomodulation. One compound however exhibits significantly improved modulatory properties of NKA induced signaling when compared to the original modulator. 2009 American Chemical Society.

NUCLEOPHILIC CHARACTERISTICS OF NUCLEOFUGIC ANIONS IN THE CLEAVAGE OF EPOXIDES BY PROTIC ACIDS AND NITRONIUM FLUOROBORATE

The cleavage of ethylene, propylene, and cyclohexene oxides by protic acids RCOOH (R= CH3, CF3) in the presence of sources of nucleophilic anions (the lithium or tetrabutylammonium salts of perchloric or substituted sulfonic acids) leads to the formation not only of 2-hydroxyalkyl carboxylates but also of significant amounts of 2-hydroxyalkyl perchlorates and sulfonates.In the reactions of the same oxides with nitronium fluoroborate and the above-mentioned salts in methylene chloride 2-perchloryl- and 2-sulfonyloxyalkyl nitrates are formed with high yields; these are the products from opening of the epoxide ring and subsequent combination of the perchlorate and substituted sulfonate ions.The investigated processes extend the range of reactions involving the concurrent combination of nucleofugic anions and can be used as a method for the production of β-hydroxy- and β-nitroxyalkyl perchlorates and sulfonates.