- SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF
-
Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.
- -
-
Paragraph 0193
(2020/10/20)
-
- An intra/intermolecular suzuki sequence to benzopyridyloxepines containing geometrically pure exocyclic tetrasubstituted alkenes
-
(Chemical Equation Presented) A route to enable the preparation of 5-benzylidenyl-benzopyridyloxepine analogues was developed to continue our research in the field of nuclear hormone receptor modulators. The key steps are1) a syn-stereoselective diboratio
- Carson, Matthew W.,Giese, Matthew W.,Coghlan, Michael J.
-
supporting information; experimental part
p. 2701 - 2704
(2009/05/26)
-
- Tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them
-
Compounds of formula (I): wherein A represents a 5, 6 or 7-membered (hetero)aromatic or non-aromatic ring,n and n′ represent 0, 1 or 2X represents an alkylene chain as defined in the description,R3 represents an aryl or heteroaryl group,one of the groups R1 and R2 represents a hydrogen atom and the other represents a group of formula (II) as defined in the description. Medicinal products containing the same which are useful in treating conditions involving a defect in apoptosis.
- -
-
Page/Page column 13
(2008/12/07)
-
- NOVEL QUINOLINE DERIVATIVES AS POTASSIUM ION CHANNEL OPENERS
-
ABSTRACT The present invention is directed to novel quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.
- -
-
Page/Page column 45
(2008/06/13)
-
- NOVEL PYRIDINE DERIVATIVES AS POTASSIUM ION CHANNEL OPENERS
-
The present invention is directed to novel pyridine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.
- -
-
Page/Page column 45
(2008/06/13)
-
- trans-2,6-, 3,6- And 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzophenanthrene-10,11-diols as dopamine agonists
-
The title compounds were synthesized by replacing the thiophene moiety of A-86929(2a) with variously substituted pyridines. Dopamine D-1 and D-2 binding and adenylate cyclase assays indicate that 4,6-diaza compounds 15 are potent and selective full D1 agonists when R1 is H or a small substituent and R2=H, with D1 binding affinity and adenylate cyclase functional potency equivalent to that of A-86929(2a).
- Gu, Yu Gui,Bayburt, Erol K.,Michaelides, Michael R.,Lin, Chun Wei,Shiosaki, Kazumi
-
p. 1341 - 1346
(2007/10/03)
-