197007-87-7Relevant articles and documents
SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF
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Paragraph 0193, (2020/10/20)
Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.
An intra/intermolecular suzuki sequence to benzopyridyloxepines containing geometrically pure exocyclic tetrasubstituted alkenes
Carson, Matthew W.,Giese, Matthew W.,Coghlan, Michael J.
supporting information; experimental part, p. 2701 - 2704 (2009/05/26)
(Chemical Equation Presented) A route to enable the preparation of 5-benzylidenyl-benzopyridyloxepine analogues was developed to continue our research in the field of nuclear hormone receptor modulators. The key steps are1) a syn-stereoselective diboratio
Tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them
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Page/Page column 13, (2008/12/07)
Compounds of formula (I): wherein A represents a 5, 6 or 7-membered (hetero)aromatic or non-aromatic ring,n and n′ represent 0, 1 or 2X represents an alkylene chain as defined in the description,R3 represents an aryl or heteroaryl group,one of the groups R1 and R2 represents a hydrogen atom and the other represents a group of formula (II) as defined in the description. Medicinal products containing the same which are useful in treating conditions involving a defect in apoptosis.
NOVEL QUINOLINE DERIVATIVES AS POTASSIUM ION CHANNEL OPENERS
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Page/Page column 45, (2008/06/13)
ABSTRACT The present invention is directed to novel quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.
NOVEL PYRIDINE DERIVATIVES AS POTASSIUM ION CHANNEL OPENERS
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Page/Page column 45, (2008/06/13)
The present invention is directed to novel pyridine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.
trans-2,6-, 3,6- And 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzophenanthrene-10,11-diols as dopamine agonists
Gu, Yu Gui,Bayburt, Erol K.,Michaelides, Michael R.,Lin, Chun Wei,Shiosaki, Kazumi
, p. 1341 - 1346 (2007/10/03)
The title compounds were synthesized by replacing the thiophene moiety of A-86929(2a) with variously substituted pyridines. Dopamine D-1 and D-2 binding and adenylate cyclase assays indicate that 4,6-diaza compounds 15 are potent and selective full D1 agonists when R1 is H or a small substituent and R2=H, with D1 binding affinity and adenylate cyclase functional potency equivalent to that of A-86929(2a).