197007-88-8Relevant articles and documents
trans-2,6-, 3,6- And 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzophenanthrene-10,11-diols as dopamine agonists
Gu, Yu Gui,Bayburt, Erol K.,Michaelides, Michael R.,Lin, Chun Wei,Shiosaki, Kazumi
, p. 1341 - 1346 (2007/10/03)
The title compounds were synthesized by replacing the thiophene moiety of A-86929(2a) with variously substituted pyridines. Dopamine D-1 and D-2 binding and adenylate cyclase assays indicate that 4,6-diaza compounds 15 are potent and selective full D1 agonists when R1 is H or a small substituent and R2=H, with D1 binding affinity and adenylate cyclase functional potency equivalent to that of A-86929(2a).
TRANS-2,6-3,6-AND 4,6-DIAZA-5,6,6a,7,8,12B-HEXAHYDROBENZO[C]PHENANTHRENE COMPOUNDS AS DOPAMINE AGONISTS
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, (2008/06/13)
A tetracyclic compound of the formula: STR1 wherein A and the atoms to which it is attached comprise a pyridine ring selected from: STR2 wherein R 1, R 2, and R 3 are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder, and methods for the preparation thereof.