- 2-mercaptoethanol synthesis
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A process comprising reacting, in a reactor having a fixed bed containing a solid catalyst which contains a zeolite, hydrogen sulfide and an oxirane in the presence of the solid catalyst to yield a reaction product with contains a mercapto-alcohol. A reactor system includes the reactor, an oxirane feed stream, a hydrogen sulfide feed stream, a fixed bed containing the solid catalyst placed inside the reactor, and an effluent stream containing the reaction product. The hydrogen sulfide and the oxirane are present in a mole ratio in a range of about 5:1 to 50:1.
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Page/Page column 20-25
(2020/07/09)
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- Preparation method of 3-mercapto-1-propanol
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The invention relates to a preparation method of 3-mercapto-1-propanol. The preparation method is characterized in that 3-mercapto-1-propanol is prepared from 3-mercaptopropionic acid as a raw material, tetrahydrofuran as a solvent and a NaBH4/BF3 system as a reducing agent by controlling reaction conditions, a solution obtained after the reaction is heated, a solid mixture is obtained and subjected to post-processing, and a finished product of 3-mercapto-1-propanol is obtained, wherein the optimal mole ratio of 3-mercaptopropionic acid, NaBH4 and a boron trifluoride tetrahydrofuran complex is 1:(1.5-1.7):(0.8-1.0). Compared with other preparation methods of 3-mercapto-1-propanol, the preparation method of 3-mercapto-1-propanol has the beneficial effects that the raw materials are lower in cost, and the cost is reduced; the reaction conditions are mild, the reaction is simple and feasible, and the operation process is safe; the yield of 3-mercapto-1-propanol can reach 80% or higher, and the product purity can reach 99.3% or higher; little pollution is caused in the preparation process, all used organic solvents can be recycled, and the method is suitable for industrial production.
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Paragraph 0012; 0013
(2017/07/22)
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- PROCESS FOR PRODUCING 3-MERCAPTO-1-PROPANOL
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3-Mercapto-1-propanol can be produced in high yield without using pyrophoric aluminum lithium hydride, by subjecting a compound of the following formula (1) to addition reaction with allyl alcohol to prepare a compound of the following formula (2) and then hydrolyzing the compound of the following formula (2) into 3-mercapto-1-propanol: wherein R1 is an alkyl group.
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Page/Page column 11; 16
(2011/04/25)
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- A general and mild synthesis of thioesters and thiols from halides
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The conversion of a wide variety of halides to thioesters by reaction with potassium thiocetate under mild conditions is described, and the generality of the method is demonstrated.
- Zheng, Tu-Cai,Burkart, Maureen,Richardson, David E.
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p. 603 - 606
(2007/10/03)
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- 7-(2-AMINOETHYL) BENZOTHIAZOLONES
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There are disclosed compounds of formula I, Ar--CH. sub.2 CH 2--NH--CR 1 R 2--X--Y I in whichAr represents a group, STR1 X represents a C. sub.1-12 alkylene chain optionally interrupted or terminated by one or more groups selected from--S(O) n--,--O--,--C(Z)--, CR 6 R. sup.7, phenylmethyne,--NR 8--,--CONH--,--NHCO--and--NHCONH--, Y represents an optionally substituted aryl or cycloalkyl group,Z represents O or S, R 1, R 2, R 5 and R 9 each independently represent hydrogen or alkyl C 1-6,R 3 and R 4 represent hydrogen, or R. sup.3 and R 4 together form a group--S--,--NR 9--or--CH 2--,R 6 and R 7 independently represent hydrogen, alkyl C 1-6, fluoro, cyano, or CF. sub.3, provided that at least one of R 6 and R 7 is other than hydrogen,R 8 represents hydrogen or alkyl C 1-6, or when X is interrupted or terminated by more than one--NR 8--group may together with another R 8 group form the chain--CH 2--CH 2--, andn represents 0, 1 or 2,and pharmaceutically acceptable derivatives thereof.Processes for their production and pharmaceutical compositions and methods of treatment involving their use are also described.
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- Sulfoboration of Cyclic Ethers - A Preparative Route to Mercaptoalkanols and Bis(hydroxyalkyl) Sulfides
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Bis(1,5-cyclooctanediylboryl) sulfide (1) reacts slowly with the cyclic ethers A-D to give O,S-bis(9-BBN)mercaptoalkanols 2a-d in excellent yields.From oxetane (E) and 1, however, 2e is obtained rapidly, which further reacts with E to yield the bis(9-BBN-oxypropyl) sulfide 3ee. 2a and c react with E to form the mixed thioethers 3ae and 3ce, respectively.The methanolysis of 2a-e leads to the O-(9-BBN)mercaptoalkanols 4a-e.The compounds 2 and 3 react with acetylacetone or with 2-aminoethanol to yield the mercaptoalkanols 7a-c, e and the bis(hydroxyalkyl) sulfides 8ae, 8ce and 8ee, resp., in high yields beside the 9-BBN-chelates 5 or 6.Key Words: Ethers, cyclic, cleavage of / Sulfoborations / Mercaptoethanols, 9-BBN derivatives of / Sulfides, bis(hydroxyalkyl), 9-BBN derivatives of
- Koester, Roland,Kucznierz, Ralf
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p. 835 - 842
(2007/10/02)
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- Cephem compounds, their production and use
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This invention relates to a compound of the formula: STR1 wherein Q is nitrogen or CH; R1 is hydrogen or a lower alkyl group which may be substituted; and ring A is a pyridine or pyridazine ring which is substituted at the ring-constituting car
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- AN EASY PREPARATION OF SIMPLE SULTINES AND HYDROXYALKANESULFINATE SALTS
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In accord with mechanistic prediction a one-pot, two-stage, controlled chlorination-hydrolysis of HO(CH2)nSH gave the sultine when n=3 or 4, and the polymeric sulfinic ester when n=5 or 6; alkaline hydrolysis of either product yielded the corresponding sodium ω-hydroxy-1-alkanesulfinate.
- King, J. F.,Rathore, Rajenda
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p. 2763 - 2766
(2007/10/02)
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- THE CHEMISTRY OF α,ω-MERCAPTOALCOHOLS IN THE PRESENCE OF DIETHOXYTRIPHENYLPHOSPHORANE. TEMEPERATURE DEPENDENCE OF CYCLODEHYDRATIONS AND S-ETHYLATIONS
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Diethoxytriphenylphosphorane (DTPP) is easily prepared by oxidative addition of triphenylphosphine with diethyl peroxide.DTPP converts a variety of mercaptoalcohols to cyclic sulfides as well as hydroxythioethers.The temperature dependence (+25 --> -25 deg C) of the product distribution has synthetic petential.
- Robinson, Philip L.,Kelly, Jeffery W.,Slayton, A. Evans
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