- One-pot synthesis of 1,3,5-triarylpyrazoles
-
A series of novel 1,3,5-triarylpyrazoles were synthesized from flavanones, arylhydrazines, and trimethyl phosphate in an one-pot procedure. Facile reaction process, easy after-reaction workshop, and good yields are the distinct characteristics of the developed protocol. The target compounds were characterized by element analysis, infrared ray (IR), 1H NMR spectra, and electrospray ionization-mass spectrometry. The structure of representative compound (C23H20N2O3, Mr = 372.42) was further confirmed by X-ray diffraction. It crystallizes in monoclinic, space group P 21/c, a = 8.9720(5), b = 24.5523(13), c = 8.9687(6) A, α = 90.0000, β = 102.6417(17), γ = 90.0000°, V = 1927.76(20) A3, Z = 4, μ(MoKα) = 0.086, F(000) = 784, Dc = 1.283 g/cm3, the final R = 0.0349 and wR = 0.0844 for 1668 observed reflections (I > 2σ(I)).
- Huang, Shufang,Ying, Huazhou,Hu, Yongzhou
-
p. 478 - 483
(2013/06/27)
-
- Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands
-
We designed a series of pyrazole-based carboxylic acids as candidate ligands of heart fatty acid binding protein (H-FABP, or FABP3), based on a comparison of the X-ray crystallographic structures of adipocyte fatty acid binding protein (FABP4)-selective inhibitor (BMS309403) complex and FABP3-elaidic acid complex. Some of the synthesized compounds exhibited dual FABP3/4 ligand activity, and some exhibited selectivity for FABP3.
- Beniyama, Yoko,Matsuno, Kenji,Miyachi, Hiroyuki
-
p. 1662 - 1666
(2013/04/10)
-
- Synthesis of pyrazole and isoxazole in triethanolamine medium
-
Reactions of 2′-hydroxy chalcone dibromides 2a-1 with phenyl hydrazine and hydrazine hydrate afford pyrazoles 1a-1 and with hydroxylamine hydrochloride give isoxazoles 5a-f in triethanolamine medium. Similarly reaction of β-diketone 3b-e with phenyl hydra
- Agrawal, Nitin N.,Soni
-
p. 532 - 534
(2008/09/18)
-
- The preparation of 2-(1-phenyl-5-phenyl or 5-substituted phenyl-1H- pyrazol-3-yl)phenols from trilithiated 2'-hydroxyacetophenone phenylhydrazone and aromatic esters
-
2'-Hydroxyacetophenone phenylhydrazone was trilithiated with excess lithium diisopropylamide, and the resulting trianion-type intermediate was condensed with a variety of aromatic esters followed by acid cyclization to 2-(1-phenyl-5-phenyl or 5-substitute
- Rampey, Mary E.,Hurst, Douglas R.,Sood, Aseem,Studer-Martinez, Shannon L.,Beam, Charles F.
-
p. 495 - 506
(2007/10/03)
-
- Lead Tetraacetate Oxidation of 1,3-Triaryl-5-hydroxyphenyl-pyrazolines
-
Lead tetraacetate oxidation of the title pyrazolines (Ia-d) leads to the pyrazoles (IIa-d) in which OH group in the 5-aryl moiety remains intact.Structures of pyrazoles (IIa-d) have been confirmed by elemental analyses and spectral data.
- Sharma, T. C.,Rojindar, S.,Berge, D. D.,Kale, A. V.
-
-
- SYNTHESIS OF SOME ISOMERIC PYRAZOLES
-
The syntheses of 3-o-hydroxyphenyl-1,5-diphenylpyrazoles (III) and 1,3-diphenyl-5-o-hydroxyphenylpyrazoles (V) by the oxidation of corresponding pyrazolines (II) with manganese dioxide and by the reaction of phenylhydrazine with 2'-hydroxychalcone dibromi
- Sharma, T. C.,Pawar, S. R.,Reddy, N. J.
-
p. 159 - 162
(2007/10/02)
-