19726-10-4

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 7327-78-8 2-[1-(2-phenylhydrazino)ethyl]phenol 
• 100-63-0 phenylhydrazine 
• 487-26-3 Flavanone 
• 100-52-7 benzaldehyde 
• 579-74-8 2-Methoxyacetophenone 
• 40524-62-7 1-(2-methoxyphenyl)-3-phenyl-2-propene-1-one 
• 95006-00-1 3-(2-methoxyphenyl)-1,5-diphenyl-2-pyrazoline 
• 1426534-15-7 3-(2-methoxyphenyl)-1,5-diphenyl-1H-pyrazole 
• 39729-11-8 2'-hydroxychalcone dibromides 
• 1214-47-7 1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 
• 118-93-4 o-hydroxyacetophenone 
• 6956-41-8 3-(2-hydroxyphenyl)-1,5-diphenyl-4,5-dihydropyrazole 
• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 

Downstream Products

• 1426533-91-6 C₂₆H₂₄N₂O₃ 
• 1426533-90-5 4-(2-(1,5-diphenyl-1H-pyrazol-3-yl)phenoxy)butanoic acid 
• 1310361-49-9 2-(2'-(1,5-diphenyl-1H-pyrazol-3-yl)biphenyl-3-yloxy)acetate acid 
• 1310361-44-4 C₃₁H₂₆N₂O₃ 
• 1426533-83-6 C₂₂H₁₅F₃N₂O₃S 

Relevant academic research and scientific papers

One-pot synthesis of 1,3,5-triarylpyrazoles

A series of novel 1,3,5-triarylpyrazoles were synthesized from flavanones, arylhydrazines, and trimethyl phosphate in an one-pot procedure. Facile reaction process, easy after-reaction workshop, and good yields are the distinct characteristics of the developed protocol. The target compounds were characterized by element analysis, infrared ray (IR), 1H NMR spectra, and electrospray ionization-mass spectrometry. The structure of representative compound (C23H20N2O3, Mr = 372.42) was further confirmed by X-ray diffraction. It crystallizes in monoclinic, space group P 21/c, a = 8.9720(5), b = 24.5523(13), c = 8.9687(6) A, α = 90.0000, β = 102.6417(17), γ = 90.0000°, V = 1927.76(20) A3, Z = 4, μ(MoKα) = 0.086, F(000) = 784, Dc = 1.283 g/cm3, the final R = 0.0349 and wR = 0.0844 for 1668 observed reflections (I > 2σ(I)).

Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands

We designed a series of pyrazole-based carboxylic acids as candidate ligands of heart fatty acid binding protein (H-FABP, or FABP3), based on a comparison of the X-ray crystallographic structures of adipocyte fatty acid binding protein (FABP4)-selective inhibitor (BMS309403) complex and FABP3-elaidic acid complex. Some of the synthesized compounds exhibited dual FABP3/4 ligand activity, and some exhibited selectivity for FABP3.

Synthesis of pyrazole and isoxazole in triethanolamine medium

Reactions of 2′-hydroxy chalcone dibromides 2a-1 with phenyl hydrazine and hydrazine hydrate afford pyrazoles 1a-1 and with hydroxylamine hydrochloride give isoxazoles 5a-f in triethanolamine medium. Similarly reaction of β-diketone 3b-e with phenyl hydra

The preparation of 2-(1-phenyl-5-phenyl or 5-substituted phenyl-1H- pyrazol-3-yl)phenols from trilithiated 2'-hydroxyacetophenone phenylhydrazone and aromatic esters

2'-Hydroxyacetophenone phenylhydrazone was trilithiated with excess lithium diisopropylamide, and the resulting trianion-type intermediate was condensed with a variety of aromatic esters followed by acid cyclization to 2-(1-phenyl-5-phenyl or 5-substitute

Lead Tetraacetate Oxidation of 1,3-Triaryl-5-hydroxyphenyl-pyrazolines

Lead tetraacetate oxidation of the title pyrazolines (Ia-d) leads to the pyrazoles (IIa-d) in which OH group in the 5-aryl moiety remains intact.Structures of pyrazoles (IIa-d) have been confirmed by elemental analyses and spectral data.

SYNTHESIS OF SOME ISOMERIC PYRAZOLES

The syntheses of 3-o-hydroxyphenyl-1,5-diphenylpyrazoles (III) and 1,3-diphenyl-5-o-hydroxyphenylpyrazoles (V) by the oxidation of corresponding pyrazolines (II) with manganese dioxide and by the reaction of phenylhydrazine with 2'-hydroxychalcone dibromi