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1-Naphthalenecarboxylicacid,1-amino-1,2,3,4-tetrahydro-,(1S)-(9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1-Naphthalenecarboxylicacid,1-amino-1,2,3,4-tetrahydro-,(1S)-(9CI)

    Cas No: 197379-82-1

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  • 197379-82-1 Structure
  • Basic information

    1. Product Name: 1-Naphthalenecarboxylicacid,1-amino-1,2,3,4-tetrahydro-,(1S)-(9CI)
    2. Synonyms: 1-Naphthalenecarboxylicacid,1-amino-1,2,3,4-tetrahydro-,(1S)-(9CI)
    3. CAS NO:197379-82-1
    4. Molecular Formula: C11H13NO2
    5. Molecular Weight: 191.23
    6. EINECS: N/A
    7. Product Categories: AMINOACID
    8. Mol File: 197379-82-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-Naphthalenecarboxylicacid,1-amino-1,2,3,4-tetrahydro-,(1S)-(9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-Naphthalenecarboxylicacid,1-amino-1,2,3,4-tetrahydro-,(1S)-(9CI)(197379-82-1)
    11. EPA Substance Registry System: 1-Naphthalenecarboxylicacid,1-amino-1,2,3,4-tetrahydro-,(1S)-(9CI)(197379-82-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 197379-82-1(Hazardous Substances Data)

197379-82-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 197379-82-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,3,7 and 9 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 197379-82:
(8*1)+(7*9)+(6*7)+(5*3)+(4*7)+(3*9)+(2*8)+(1*2)=201
201 % 10 = 1
So 197379-82-1 is a valid CAS Registry Number.

197379-82-1Downstream Products

197379-82-1Relevant articles and documents

Candida antarctica Lipase B in a chemoenzymatic route to cyclic α-quaternary α-amino acid enantiomers

Li, Xiang-Guo,Rantapaju, Maria,Kanerva, Liisa T.

experimental part, p. 1755 - 1762 (2011/05/06)

Kinetic resolution of three cyclic quaternary ethyl 1-amino-2,3-dihydro-1H- indene-1-carboxylates and both 1- and 2-amino-1,2,3,4-tetrahydronaphthalene analogues have been studied. Interesterification with butyl butanoate and Candida antarctica lipase B accomplished the task. The enantiomers of all 1-amino analogues reacted with excellent enantioselectivity (enantiomeric ratio er greater than 200), whereas the 2-amino analogue was not enantioselective (er = 4). Amino acid enantiomers were finally obtained as their respective hydrochlorides with almost maximum theoretical yields. For the first time, a lipase enzyme was effectively used in the kinetic resolution of cyclic α-quaternary α-amino esters. Copyright

Efficient biocatalytic synthesis of highly enantiopure α-alkylated arylglycines and amides

Wang, Mei-Xiang,Lin, Shuan-Jun,Liu, Jun,Zheng, Qi-Yu

, p. 439 - 445 (2007/10/03)

A number of racemic α-alkylarylglycine amides including 1-amino-1-carbamoyl-1,2,3,4-tetrahydronaphthalene underwent efficient biocatalytic hydrolysis under very mild conditions to afford the corresponding (S)-α-alkylarylglycines and (R)-α-alkylarylglycine

Enantioselective synthesis of benzocyclic α,α-dialkyl-amino acids: New insight into the solvent dependent stereoselectivity of the TMSCN addition to phenylglycinol derived imines

Warmuth, Ralf,Munsch, Tamara E,Stalker, Robert A,Li, Bing,Beatty, Alicia

, p. 6383 - 6397 (2007/10/03)

Different benzocycloalkane-1-amino-1-carboxylic acids 1a-e have been synthesized via an asymmetric Strecker reaction using (S)-α-methylbenzylamine and (R)-phenylglycinol as chiral auxiliaries. The Zn2+-catalyzed addition of HCN to (S)-α-methylbenzylamine derived ketimines of 1-tetralone (8a) and 1-benzosuberone (8b) yielded mixtures of diastereomeric aminonitriles (1S,1′S)-10a/(1R,1′S)-10a (10:1 ratio) and (1R,1′S)-10b/(1S,1′S)-10b (56:44 ratio), respectively. These aminonitriles are converted to amino acids 1a,b in two steps. The addition of TMSCN to the (R)-phenylglycinol derived ketimines of 8a, 8b, 1-indanone (8c), 7-fluoro-1-tetralone (8d), 7-fluoro-1-benzosuberone (8e) yielded mixtures of diastereomeric trimethylsilylated aminonitriles (1S,1′R)-14a-e/(1R,1′R)-14a-e. The addition proceeded with diastereofacial selectivities ranging from 1:2.9 to 1:25. The selectivity was found to be temperature and solvent dependent. The diastereomeric ratio (dr) of aminonitriles (1S,1′R)-14a/(1R,1′R)-14a increased in different solvents in the order methanol2Cl2 (1:2.5)32Cl 2. In the pure THF, toluene, CHCl3, or CH2Cl2 kinetic product mixtures were formed, whereas the presence of methanol led to thermally equilibrated product mixtures. This solvent dependent change of the product dr is interpreted with a change in the TMSCN addition mechanism. Hydrolysis of the aminonitrile mixtures (1S,1′R)-14a-c/(1R,1′R)-14a-c and oxidative cleavage of the auxiliary yielded 1a-c, which showed the (S)-configuration as the major isomer.

Spiro hydantoin aldose reductase inhibitors

Sarges,Schnur,Belletire,Peterson

, p. 230 - 243 (2007/10/02)

Sorbitol formation from glucose, catalyzed by the enzyme aldose reductase, is believed to play a role in the development of certain chronic complications of diabetes mellitus. Spiro hydantoin derived from five- and six-membered ketones fused to an aromatic ring or ring system inhibit aldose reductase isolated from calf lens. In vivo these compounds are potent inhibitors of sorbitol formation in sciatic nerves of streptozotocinized rats. Optimum in vivo activity is reached in spiro hydantoins derived from 6-halogenated 2,3-dihydro-4H-1-benzopyran-4-ones (4-chromanones). In 2,4-dihydro-6-fluorospirol[4H-1-benzopyran-4,4'-imidazolidine]-2',5'- ione, the activity resides exclusively in the 4S isomer, compound 115 (CP-45,634, USAN: sorbinil). This compound is currently being used to test, in humans, the value of aldose reductase inhibitors in the therapy of diabetic complications.

Imidazolone derivatives

-

, (2008/06/13)

A series of novel spiro-imidazolone compounds and their pharmaceutically acceptable acid addition salts are disclosed. These particular compounds are useful in therapy as agents for the control of certain chronic diabetic complications. 3',4'-Dihydro-spiro-[imidazolidine-4,1'(2'H)naphthalene]-5-one represents a typical and preferred member compound. Methods for preparing all these compounds from known hydantoin starting materials are provided.

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