197584-93-3Relevant articles and documents
HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK
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, (2014/05/20)
Disclosed herein are new heterocyclic compounds of Formula IIa: and compositions thereof, and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
Diversity-oriented synthesis for novel, selective and drug-like inhibitors for a phosphatase from Mycobacterium tuberculosis
He, Rongjun,Bai, Yunpeng,Yu, Zhi-Hong,Wu, Li,Gunawan, Andrea Michelle,Zhang, Zhong-Yin
, p. 1496 - 1499 (2014/12/10)
Mycobacterium protein tyrosine phosphatase B (mPTPB) is a potential drug target of tuberculosis (TB). Using small molecule inhibitors of mPTPB could be a treatment to overcome emerging TB drug resistance. Using a Diversity-Oriented Synthesis (DOS) strateg