Benzoic acid, 4-amino-2-hydroxy-5-nitro- (9CI)

Base Information

• Chemical Name: Benzoic acid, 4-amino-2-hydroxy-5-nitro- (9CI)
• CAS No.: 197584-93-3
• Molecular Formula: C7H6 N2 O5
• Molecular Weight: 198.135
• Mol file: 197584-93-3.mol

Synonyms:4-Amino-5-nitrosalicylicacid

Chemical Property of Benzoic acid, 4-amino-2-hydroxy-5-nitro- (9CI)

Chemical Property:

• PSA: 129.37000
• LogP: 1.68520

Purity/Quality:

4-Amino-2-hydroxy-5-nitrobenzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-amino-2-hydroxy-5-nitro- (9CI)

There total 8 articles about Benzoic acid, 4-amino-2-hydroxy-5-nitro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-acetamido-2-hydroxy-5-nitrobenzoic acid (82378-91-4) → 4-amino-2-hydroxy-5-nitrobenzoic acid (197584-93-3)

Guidance literature:

With hydrogenchloride; In water; for 2h; Reflux;

Reference yield:

C12H12N2O7 → 4-amino-2-hydroxy-5-nitrobenzoic acid (197584-93-3)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 12h;

DOI:10.1039/c4md00099d

Reference yield:

4-acetamidosalicylic acid (50-86-2) → 4-amino-2-hydroxy-5-nitrobenzoic acid (197584-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated H₂SO₄; concentrated aqueous HNO₃

2: aqueous NaOH

With sodium hydroxide; sulfuric acid; nitric acid;

upstream raw materials:

4-acetamido-2-hydroxy-5-nitrobenzoic acid

4-benzoylamino-2-hydroxy-5-nitro-benzoic acid

4-benzoylamino-2-hydroxybenzoic acid

4-acetamidosalicylic acid

Downstream raw materials:

methyl 4,5-diamino-2-hydroxybenzoate