197960-31-9

Basic information

• Product Name: 2-CYANO-5-METHYLBENZENESULFONYL CHLORIDE
• Synonyms: 2-CYANO-5-METHYLBENZENESULFONYL CHLORIDE;2-cyano-5-methylbenzenesulphonyl chloride;Benzenesulfonyl chloride, 2-cyano-5-methyl- (9CI);2-(Chlorosulphonyl)-4-methylbenzonitrile, 3-(Chlorosulphonyl)-4-cyanotoluene
• CAS NO: 197960-31-9
• Molecular Formula: C₈H₆ClNO₂S
• Molecular Weight: 215.66
• Product Categories: SULFONYLHALIDE
• Mol File: 197960-31-9.mol

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 382°Cat760mmHg
• Flash Point: 184.9°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 4.86E-06mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 2-CYANO-5-METHYLBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-5-METHYLBENZENESULFONYL CHLORIDE(197960-31-9)
• EPA Substance Registry System: 2-CYANO-5-METHYLBENZENESULFONYL CHLORIDE(197960-31-9)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 197960-31-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-CYANO-5-METHYLBENZENESULFONYL CHLORIDE is used as a key intermediate for the synthesis of various pharmaceuticals due to its ability to facilitate the formation of new chemical entities that possess therapeutic properties.
Used in Dye Industry:
In the dye industry, 2-CYANO-5-METHYLBENZENESULFONYL CHLORIDE is utilized as a building block for the creation of dyes, contributing to the development of colorants with specific characteristics required for various applications.
Used in Agrochemical Industry:
2-CYANO-5-METHYLBENZENESULFONYL CHLORIDE is employed as a precursor in the production of agrochemicals, playing a role in the synthesis of compounds that are used to protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
2-CYANO-5-METHYLBENZENESULFONYL CHLORIDE is used as a reagent in organic synthesis for its capacity to react with nucleophiles, enabling the formation of a wide range of chemical compounds that are valuable in research and commercial applications.

InChI:InChI=1/C8H6ClNO2S/c1-6-2-3-7(5-10)8(4-6)13(9,11)12/h2-4H,1H3

Upstream product

• 26830-96-6 5-methyl-2-cyanoaniline 

Downstream Products

• 1426214-83-6 2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide 
• 1426214-91-6 N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-fluoro-5-methyl-benzenesulfonamide 
• 1426214-86-9 N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide 
• 197960-32-0 3-(2-cyano-5-methylphenylsulfonyloxy)-5-methylphenol 

Relevant articles and documents

AMIDINOHYDRAZONES AS PROTEASE INHIBITORS

Amidino and benzamidino compounds, including compounds of the formula: I wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.

AMIDINOHYDRAZONES AS PROTEASE INHIBITORS

Amidino and benzamidino compounds, including compounds of the formula: STR1 wherein R 1-R 4, R 6-R 9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.