19797-32-1

Basic information

• Product Name: Benzenesulfonamide,3,5-dichloro-
• Synonyms: 3,5-Dichlorobenzenesulfonamide
• CAS NO: 19797-32-1
• Molecular Formula: C₆H₅Cl₂NO₂S
• Molecular Weight: 226.0804
• Product Categories: Sulfur Compounds;Benzenes;Fluorobenzene;Benzene derivates;Organic Building Blocks;Sulfonamides/Sulfinamides
• Mol File: 19797-32-1.mol

Chemical Properties

• Melting Point: 161-165℃
• Boiling Point: 395.598 °C at 760 mmHg
• Flash Point: 193.051 °C
• Appearance: /
• Density: 1.589 g/cm³
• Vapor Pressure: 1.82E-06mmHg at 25°C
• Refractive Index: 1.602
• PKA: 9.54±0.60(Predicted)
• CAS DataBase Reference: Benzenesulfonamide,3,5-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide,3,5-dichloro-(19797-32-1)
• EPA Substance Registry System: Benzenesulfonamide,3,5-dichloro-(19797-32-1)

Safety Data

• Hazard Codes: Xi:Irritant
• Safety Statements: S22:; S24/25:
• WGK Germany: 3
• RTECS: DB1670000
• Hazardous Substances Data: 19797-32-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Benzenesulfonamide, 3,5-dichlorois used as a reaction intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with specific therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, Benzenesulfonamide, 3,5-dichloroserves as a key intermediate, facilitating the creation of a range of organic compounds with diverse applications.
Used in Dye and Pigment Manufacturing:
Benzenesulfonamide, 3,5-dichlorois utilized in the production of dyes and pigments, where its chemical properties contribute to the color and stability of these products.

InChI:InChI=1/C6H5Cl2NO2S/c7-4-1-5(8)3-6(2-4)12(9,10)11/h1-3H,(H2,9,10,11)

Upstream product

• 705-21-5 3,5-dichlorobenzensulfonyl chloride 

Downstream Products

• 1131395-12-4 3,5-dichloro-N-[6-(5-methyl-[1,2,4]oxadiazol-3-yl)-naphthalen-1-yl]-phenylsulphonamide 
• 1254305-47-9 C₁₅H₇Cl₃F₃N₃O₃S 
• 1263313-42-3 3,5-dichloro-N-[2-(2,2-dimethyl-propionyl)-phenyl]-benzenesulfonamide 
• 1057257-36-9 C₂₈H₂₀Cl₂N₂O₄S 
• 19797-38-7 N-phenyl-3,5-dichlorobenzenesulfonamide 
• 133514-50-8 C₁₂H₈Cl₃NO₂S 
• 1173838-90-8 N-(4-fluorophenyl)-3,5-dichlorobenzenesulfonamide 
• 1138722-85-6 C₂₅H₂₂Cl₄N₂O₄S 
• 1057256-50-4 3,5-Dichloro-N-[2-(1H-indol-4-yloxy)-acetyl]-benzenesulfonamide 
• 1044266-22-9 C₁₂H₇Cl₂F₃N₂O₂S 
• 817200-64-9 1,1-dimethylethyl[(3,5-dichlorophenyl)sulfonyl]carbamate 
• 84615-17-8 C₆H₄Cl₂N₂O₄S 
• 19797-35-4 4-(3,5-dichloro-benzenesulfonyl)-morpholine 

Relevant articles and documents

Cu(II)-catalyzed decarboxylation/elimination of N-arylsulfonyl amino acids to primary aryl sulfonamides

A novel protocol for CuO-catalyzed decarboxylation/elimination of N-arylsulfonyl amino acids was developed. It is the first example of using an accessible amino acid as an ammonia synthetic equivalent for the synthesis of primary aryl sulfonamides via oxidative decarboxylation/elimination reactions. The present protocol shows excellent functional group tolerance and provides an efficient method for the synthesis of primary aryl sulfonamides in excellent yields.

Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus

Vancomycin is mainly used as an antibacterial agent of last resort, but recently vancomycin-resistant bacterial strains have been emerging. Although new antimicrobials have been developed in order to overcome drug-resistant bacteria, many are structurally

N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase

Steroid sulfatase (STS) is an attractive target for a range of oestrogen- and androgen-dependent diseases. In search of novel chemotypes of STS inhibitors, we had previously identified nortropinyl-arylsulfonylureas 1; however, while these compounds were good inhibitors of purified STS (lowest Ki = 76 nM), they showed only weak inhibition of STS activity in cells (lowest IC50 around 2 μM). Extended structure-activity relationship studies involving modification of the phenylacetyl side chain and replacement of the nortropine element by simpler scaffolds led to the discovery of N-acyl arylsulfonamides, more specifically N-(Boc-piperidine-4-carbonyl)- benzenesulfonamides, as STS inhibitors, some of which exhibit improved cellular potency (best IC50 = 270 nM).

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Use of a compound of formula (I): or a salt, solvate or a physiologically functional derivative thereof, for the manufacture of a medicament for treating a disorder mediated by GlyT1, such as foe example schizophrenia, is disclosed, wherein R1,