- Methionine and buthionine sulfoximines: Syntheses under mild and safe imidation/oxidation conditions
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Methionine and buthionine sulfoximines (MSO and BSO) are non-natural amino acids known to inhibit the biosynthesis of glutathione (GSH). The current syntheses of these biologically active molecules involve harsh reaction conditions and the use of hazardou
- Buglioni, Laura,Bizet, Vincent,Bolm, Carsten
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supporting information
p. 2209 - 2213
(2014/07/21)
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- QUANTITATIVE SEPARATION AND ANALYSIS OF DIASTEREOMERS OF L-METHIONINE-S,R-SULFOXIMINE VIA CYCLIC N-BLOCKED DERIVATIVES
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The diastereomers of L-methionine-S,R-sulfoximine, blocked at α-N with phthaloyl, then cyclized with Ac2O to form 3,4,5,6-tetrahydro-1-methyl-3-oxo-4-(N-phthalimido)-1,2-thiazine-1-oxide, could be easily separated by fractional crystallization or HPLC, whereas the parent compounds were very difficult to separate.
- Sugiyama, Yuichi,Wedler, Frederick C.
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p. 1471 - 1474
(2007/10/02)
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