198474-90-7

Basic information

• Product Name: BOC-L-3,4-Difluorophe
• Synonyms: 3,4-DIFLUORO-L-PHENYLALANINE, BOC PROTECTED;BOC-PHE(M,P-F2)-OH;BOC-PHE(3,4-F 2)-OH;BOC-PHE(3,4-DIF)-OH;BOC-L-PHE(3,4-F2)-OH;BOC-L-3,4-DIFLUOROPHE;BOC-L-3,4-DIFLUOROPHENYLALANINE;BOC-3,4-DIFLUORO-L-PHENYLALANINE
• CAS NO: 198474-90-7
• Molecular Formula: C₁₄H₁₇F₂NO₄
• Molecular Weight: 301.29
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;chiral;Amino Acid Derivatives;Peptide
• Mol File: 198474-90-7.mol

Chemical Properties

• Melting Point: 95-105°C
• Boiling Point: 430.4 °C at 760 mmHg
• Flash Point: 214.1 °C
• Appearance: white to light yellow crystal powder
• Density: 1.27 g/cm³
• Vapor Pressure: 3.57E-08mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: Store at 0°C
• Solubility: slightly sol. in Methanol
• PKA: 3.79±0.10(Predicted)
• BRN: 8566144
• CAS DataBase Reference: BOC-L-3,4-Difluorophe(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-L-3,4-Difluorophe(198474-90-7)
• EPA Substance Registry System: BOC-L-3,4-Difluorophe(198474-90-7)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 198474-90-7(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C14H17F2NO4/c1-14(2,3)21-13(20)17-11(12(18)19)7-8-4-5-9(15)10(16)6-8/h4-6,11H,7H2,1-3H3,(H,17,20)(H,18,19)/t11-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 31105-90-5 (L)-2-amino-3-(3,4-difluorophenyl)propanoic acid 
• 15017-45-5 2-Acetylamino-2-(3,4-difluorobenzyl)malonic acid diethyl ester 
• 85118-01-0 alpha-bromo-3,4-difluorotoluene 
• 266360-51-4 2-acetylamino-3-(3,4-difluoro-phenyl)-propionic acid 

Downstream Products

• 949912-56-5 [2-(3,4-difluoro-phenyl)-1-formyl-ethyl]-carbamic acid tert-butyl ester 
• 949912-99-6 (S)-2-Amino-N-[(S)-1-(3,4-difluoro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide 
• 949913-02-4 5-[1,2]Dithiolan-3-yl-pentanoic acid {(S)-1-[(S)-1-(3,4-difluoro-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethylcarbamoyl]-2-methyl-propyl}-amide 
• 343566-43-8 (2R)-3-(3',4'-difluorophenyl)-2-hydroxypropionic acid 
• 1194096-58-6 [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 1239576-61-4 1,1-dimethylethyl [(1S)-2-(3,4-difluorophenyl)-1-(hydroxymethyl)ethyl]carbamate 
• 1300196-70-6 (S)-N-{(S)-2-(3,4-difluoro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-2-(isopropyl-methyl-amino)-propionamide 
• 1300196-69-3 (R)-1-methyl-pyrrolidine-2-carboxylic acid {(S)-2-(3,4-difluoro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-amide 
• 1300197-90-3 {(S)-2-(3,4-difluoro-phenyl)-1-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-carbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 603137-53-7 C₃₃H₄₄F₂N₆O₇S₂ 
• 949912-52-1 [2-(3,4-difluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

A complete set of difluorophenylalanines in the L-configuration [L- (F2)Phe] (namely, L-(2,3-F2)Phe, L-(2,4-F2)Phe, L-(2,5-F2)Phe, L-(2,6- F2)Phe, L-(3,4-F2)Phe, L-(3,5-F2)Phe) w