19878-10-5

Basic information

• Product Name: linoleylanilide
• Synonyms: linoleylanilide;LINOLEOYLANILIDE;LINOLEICACIDANILIDE;(9Z,12Z)-N-Phenyl-9,12-octadecadienamide;N-Phenyllinolamide
• CAS NO: 19878-10-5
• Molecular Formula: C₂₄H₃₇NO
• Molecular Weight: 355.56
• Mol File: 19878-10-5.mol

Chemical Properties

• Boiling Point: 518.2°Cat760mmHg
• Flash Point: 320.8°C
• Appearance: /
• Density: 0.951g/cm³
• Vapor Pressure: 7.68E-11mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: linoleylanilide(CAS DataBase Reference)
• NIST Chemistry Reference: linoleylanilide(19878-10-5)
• EPA Substance Registry System: linoleylanilide(19878-10-5)

Safety Data

• Hazardous Substances Data: 19878-10-5(Hazardous Substances Data)

Usage

Definition

ChEBI: A fatty amide conjugate of linoleic acid and aniline.

InChI:InChI=1/C24H37NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-24(26)25-23-20-17-16-18-21-23/h6-7,9-10,16-18,20-21H,2-5,8,11-15,19,22H2,1H3,(H,25,26)/b7-6-,10-9-

Upstream product

• 60-33-3 linoleic acid 
• 623-04-1 4-aminobenzenemethanol 
• 1416720-33-6 (9Z,12Z)-N-(4-(hydroxymethyl)phenyl)octadeca-9,12-dienamide 
• 7459-33-8 linoleyl chloride 
• 62-53-3 aniline 

Relevant articles and documents

Synthesis, characterization and corrosion inhibition studies of polyunsaturated fatty acid derivatives on the acidic corrosion of mild steel: Experimental and computational studies

In an effort to make an efficient and benign CI for the purpose of acidizing, a novel range of new derivatives of polyunsaturated fatty acids (PUFA) were prepared from a group of amines and Z-9,12-octadecadienoic acid with Excellent yields. Elemental analysis, FTIR, 13C NMR and 1H NMR was employed to realize a description for the newly manufactured compound. The inhibitive action of synthesized amides was examined by means of potentiodynamic polarization techniques and weight loss measurements in 1.00 M HCl. Derivatives of Z-9,12-octadecadienoic acid amides (DA) were found to obey the Langmuir adsorption model. The hydrophobic nature of mild steel (MS) was revealed by measurement of the contact angle in the presence of CI. The experimental findings were found to be supported by quantum chemical calculations. Inhibition efficiencies were computed for various DA concentrations for inhibition against the wear of MS in 100.00 ml of 1.00 M HCl, with exposure for four days at temperatures ranging from 298 to 333 K. For a DA concentration of 100 ppm, every inhibitor molecule showed outstanding percentage inhibition efficiencies in 1.00 M HCl. Compounds 2, 3, 4, 5, 6, 7, 8 and 9 offered a robust percentage inhibition efficiency of 92.90, 86.6, 49.8, 82.7, 85.9, 96.70, 94.30 and 91.30, correspondingly, at 100 ppm. The interaction of the p-electrons in compounds with low-energy, empty Fe d-orbitals helped the inhibitive molecules (IMs) to experience adsorption and inhibit the process of anodic dissolution. When Tafel plots were employed for the compounds used in the electrochemical method, similar findings were obtained for the percentage inhibition efficiencies. Compound adsorption on the MS surface was discovered to obey Arrhenius and Transition state plots in 1.00 M HCl.

Synthesis and biological screening of a library of macamides as TNF-α inhibitors

Thirty-five macamide analogues were synthesised by modifying the initial molecular structure. The resulting structures were confirmed using NMR and MS. Cytotoxicity and the anti-inflammatory activity of these synthetic macamides were evaluated in the THP-1 cell line. Preliminary biological evaluation indicated that most of these synthetic macamides did not present cytotoxicity (MTT assay) in the tested cell line with respect to the control (actinomycin D). Regarding the anti-inflammatory activity, several analogues had a greater potential for inhibition of TNF-α than natural macamides. Synthetic macamide 4a was the most active (IC50 = 0.009 ± 0.001 μM) compared to the C87 (control). Through looking at the link between the chemical structure and the activity, our study proves that changes made to natural macamides at the level of the alkyl chain, the benzyl position, the amide bond, and the addition of two methyl groups to the aromatic ring (meta position) lead us to obtaining new macamides with greater anti-inflammatory activity. This journal is

A METHOD OF TREATING PERIPHERAL INFLAMMATORY DISEASE

An active for use in the treatment or inhibition of an inflammatory disease associated with over-activation of Toll-like Receptor 4 (TLR4), Toll-like Receptor 2 (TLR2) and Myeloid differentiating protein 88 (Myd88) adaptor-like protein (Mal) while maintaining a subject's ability to respond normally to a pathogen, in which the active is an oleamide or a derivative thereof.

An efficient dehydroxymethylation reaction by a palladium catalyst

A general method for selective dehydroxymethylation has been discovered by using widely available Pd(OAc)2. The present study offers a new synthetic strategy for the regioselective functionalization by employing the steric, electronic and coordinating nature of the hydroxymethyl (-CH 2OH) group temporarily.