623-04-1

Usage

Chemical Properties

white to light yellow crystal powde

Uses

4-Aminobenzyl alcohol is used in the synthesis of 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino}benzyl ester. It is also used as an intermediate in organic synthesis and pharmaceutical products.

InChI:InChI=1/C7H9NO/c8-7-3-1-6(5-9)2-4-7/h1-4,9H,5,8H2

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 62-23-7 4-nitro-benzoic acid 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 619-73-8 4-nitrobenzyl chloride 
• 100-52-7 benzaldehyde 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 26798-33-4 (p-nitrophenyl)methanethiol 
• 99-99-0 1-methyl-4-nitrobenzene 
• 619-45-4 4-methoxycarbonyl aniline 
• 94-09-7 p-aminoethylbenzoate 
• 78981-72-3 α-<(tert-butyloxycarbonyl)lysyl>amido>benzyloxycarbonyl>-p'-nitroanilide 
• 99-77-4 ethyl 4-nitrobenzoate 

Downstream Products

• 81115-77-7 4-(4-amino-benzyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 101-77-9 4,4'-diamino diphenyl methane 
• 179057-17-1 N-[4-(hydroxymethyl)phenyl] benzamide 
• 106-49-0 p-toluidine 
• 62-53-3 aniline 
• 467-62-9 pararosaniline 
• 65926-74-1 1-(4-(hydroxymethyl)phenyl)-2-phenyldiazene 
• 13640-67-0 4-benzenesulfonylmethyl-aniline 
• 143330-51-2 4-benzyl alcohol 
• 448963-33-5 C₃₀H₃₅N₇O₇ 
• 448963-29-9 {(S)-1-[(S)-1-(4-Hydroxymethyl-phenylcarbamoyl)-4-ureido-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester 
• 220369-85-7 Z-Lys(alloc)-p-aminobenzyl alcohol 
• 159858-07-8 N-Cbz-Val-Cit-4-aminobenzyl alcohol 
• 448963-30-2 benzyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate 

Relevant academic research and scientific papers

Development of Efficient Copper-Based MOF-Derived Catalysts for the Reduction of Aromatic Nitro Compounds

Two copper-based Cu3(btc)2 and Cu(Im)2 metal–organic frameworks are synthesized and annealed to form nanoporous Cu/Cu2O@C and Cu@N-C nanoparticles for utilization as catalysts in the reduction reaction of aromatic nitro compounds to aromatic amines. All synthesized MOF compounds and MOF-derived nanoparticles are characterized using XRD, Raman spectroscopy, TGA, SEM-EDX, and XPS methods. Also, the pore-size distribution and surface area of the MOF-derived Cu/Cu2O@C and Cu@N-C nanoparticles are characterized by the BJH and BET methods. After characterization, the catalysts Cu/Cu2O@C and Cu@N-C are catalytically tested for the reduction reactions of various aromatic nitro compounds chemically by monitoring with a UV/Vis spectrometer. Both catalysts exhibit remarkable results compared with those in the literature. Also, the Cu/Cu2O@C catalyst shows better results than the Cu@N-C catalyst.

Detection of L-alanylaminopeptidase activity in microorganisms using fluorogenic self-immolative enzyme substrates

A series of fluorogenic enzymatic substrates that incorporate a self-immolative spacer were synthesised for the purpose of identifying L-alanylaminopeptidase activity in microorganisms in agar media. These substrates resulted in the generation of fluoresc

The X-ray Structure of 4-Aminobenzyl alcohol (4-Aminophenylmethanol)

A second polymorph of 4-aminobenzyl alcohol [orthorhombic, a = 8.95051(15), b = 5.8248(1), c = 12.1645(2) ?, space group Pna21] shows a “herringbone” structure with stacks of hydrogen-bonded molecules when viewed down the b-axis. Graphical Abst

Direct Heterogenization of the Ru-Macho Catalyst for the Chemoselective Hydrogenation of α,β-Unsaturated Carbonyl Compounds

In this study, a commercially available homogeneous pincer-type complex, Ru-Macho, was directly heterogenized via the Lewis acid-catalyzed Friedel-Crafts reaction using dichloromethane as the cross-linker to obtain a heterogeneous, pincer-type Ru porous organometallic polymer (Ru-Macho-POMP) with a high surface area. Notably, Ru-Macho-POMP was demonstrated to be an efficient heterogeneous catalyst for the chemoselective hydrogenation of α,β-unsaturated carbonyl compounds to their corresponding allylic alcohols using cinnamaldehyde as a model compound. The Ru-Macho-POMP catalyst showed a high turnover frequency (TOF = 920 h-1) and a high turnover number (TON = 2750), with high chemoselectivity (99%) and recyclability during the selective hydrogenation of α,β-unsaturated carbonyl compounds.

A novel water-dispersible and magnetically recyclable nickel nanoparticles for the one-pot reduction-Schiff base condensation of nitroarenes in pure water

In this work, a heterogeneous nanocatalyst called Ni-Fe3O4@Pectin~PPA ~ Piconal was first synthesized, which was investigated as a bifunctional catalyst containing nickel functional groups. On the other hand, this Ni-Fe3O4@Pectin~PPA ~ Piconal catalyst in aqueous solvents shows a very effective performance at ambient temperature for the nitroarene reduction reaction with sodium borohydride, for which NaBH4 is considered as a reducing agent. This is a novelty magnetic catalyst that was approved by various methods, including Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), Dynamic light scattering (DLS), Transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), Inductively coupled plasma (ICP), Energy-dispersive X-ray spectroscopy (EDX), and Field emission scanning electron microscopy (FESEM) analyses. From the satisfactory results obtained from the reduction of nitrogen, this catalytic system is used for a one-pot protocol containing a reduction-Schiff base concentration of diverse nitroarenes. It was corroborated with the heterogeneous catalytic experiments on the one-pot tandem synthesis of imines from nitroarenes and aldehydes. Finally, the novel Ni-Fe3O4@Pectin~PPA ~ Piconal catalyst could function as a more economically desirable and environmentally amicable in the catalysis field. The favorable products are acquired in good to high performance in the attendance of Ni-Fe3O4@Pectin~PPA ~ Piconal as a bifunctional catalyst. This catalyst can be recycled up to six steps without losing a sharp drop.

Silver nanoparticles supported on P, Se-codoped g-C3N4 nanosheet as a novel heterogeneous catalyst for reduction of nitroaromatics to their corresponding amines

P, Se-codoped g-C3N4 (PSeCN) nanosheet was in situ prepared by facile thermal polymerization of melamine, phosphonitrilic chloride trimer, and selenium black powder as the precursors. It was found as a suitable support for the immobilization of silver nanoparticles (Ag NPs). The prepared nanocatalyst was fully characterized via standard analysis methods including EDX, ICP-OES, XRD, FT-IR, SEM, TEM, and BET. This PSeCN/Ag nanocatalyst with a higher specific surface area compared with CN, showed excellent catalytic activity towards the reduction of several nitroaromatic compounds using sodium borohydride (NaBH4) in short reaction times with high efficiency and good selectivity in water as a green solvent. Significantly, the above-mentioned nanocomposite could be reused six times without appreciable loss of its catalytic activity.

Crosslinked polymer encapsulated palladium nanoparticles for catalytic reduction and Suzuki reactions in aqueous medium

Acrylamide and N-isopropylacrylamide were copolymerized in the presence of a N,N-methylenebisacrylamide crosslinker to obtain poly(N-isopropylacrylamide-co-acrylamide) [P(NA)] polymer colloidal particles. Pd nano crystals with diameter of 4–8 nm were loaded into the [P(NA)] microgels by reduction of [PdCl4]-2 within dispersion of polymer microgels. The Pd NPs-loaded hybrid microgels were analysed by TEM, STEM, EDX and XRD. The catalytic ability of the Pd-[P(NA)] system was investigated towards reductive transformation of nitroarenes into corresponding aryl amines and Suzuki coupling transformation in a green solvent, H2O. The progress of catalytic reaction was examined by thin layer chromatography (TLC). Different reactants were effectively converted into their corresponding products with great to fabulous yields (extending from 75 to 97%) under gentle reaction conditions. The Pd-[P(NA)] catalyst is stable for long time and can be utilized numerous times without any notable loss in its catalytic action.

Chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes using carbon-supported palladium catalytic system in water

Developing and/or modifying fundamental chemical reactions using chemical industry-favorite heterogeneous recoverable catalytic systems in the water solvent is very important. In this paper, we developed convenient, green, and efficient approaches for the chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes in the presence of the recoverable heterogeneous carbon-supported palladium (Pd/C) catalytic system in water. The utilize of the simple, effective, and recoverable catalyst and also using of water as an entirely green solvent along with relatively short reaction times and good-to-excellent yields of the desired products are some of the noticeable features of the presented synthetic protocols. Graphic abstract: [Figure not available: see fulltext.].

Copper nanoparticles (CuNPs) catalyzed chemoselective reduction of nitroarenes in aqueous medium

Abstract: A procedure for practical synthesis of CuNPs from CuSO4·5H2O is established, under appropriate reaction conditions, using rice (Oryza sativa) as an economic source of reducing as well as a stabilizing agent. Optical and microscopic techniques are employed for the characterization of the synthesized CuNPs and the sizes of the particles were found to be in the range of 8 ± 2 nm. The nanoparticles are used as a catalyst for chemoselective reduction of aromatic nitro compounds to corresponding amines under ambient conditions and water as a reaction medium. Graphic abstract: CuNPs are synthesized using hydrolysed rice and used as catalyst for chemoselective reduction of nitroarenes to their corresponding amines in water. [Figure not available: see fulltext.]

Synthesis of CoFe2O4@Pd/Activated carbon nanocomposite as a recoverable catalyst for the reduction of nitroarenes in water

Efficient reduction of nitro compounds into amines is an important industrial transformation. So, it is a great deal to design new catalysts for efficient reduction of the nitro compounds especially in water. In this work, a new magnetic Pd/activated carbon nanocomposite (CoFe2O4@Pd/AC) was synthesized via metal-impregnation-pyrolysis method. The CoFe2O4@Pd/AC was fully characterized by FT-IR, PXRD, FESEM, TEM, VSM, EDX-mapping and BET techniques. The results showed that CoFe2O4@Pd/AC is a highly reactive and easily recoverable magnetic catalyst for the reduction of the nitro compounds by using NaBH4 in water. For instance, aniline was obtained in high yield (99%) after 75 ?min at 25 ?C by using just 6 ?mg of the catalyst. In addition, CoFe2O4@Pd/AC was recovered by a simple magnetic decantation and it exhibits stable activity and remains intact during the catalytic process with no significant loss in activity (8 cycles).