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3-Methoxy-4-(1,3-oxazol-5-yl)aniline, also known as MOA, is an organic compound with the molecular formula C10H10N2O2. It is a pale yellow crystalline solid that is soluble in organic solvents such as ethanol and ether. 3-METHOXY-4-(1,3-OXAZOL-5-YL)ANILINE is known for its chemical reactivity and is commonly used in the manufacturing of pharmaceuticals and dyes, as well as in various applications within the chemical industry. It has a melting point of 112-115°C and is considered a building block for the synthesis of other organic compounds. Due to its potential health hazards upon exposure, researchers are advised to handle this chemical with care.

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  • 198821-79-3 Structure
  • Basic information

    1. Product Name: 3-METHOXY-4-(1,3-OXAZOL-5-YL)ANILINE
    2. Synonyms: 3-METHOXY-4-(1,3-OXAZOL-5-YL)ANILINE;BenzenaMine, 3-Methoxy-4-(5-oxazolyl)-;3-Methoxy-4-(oxazol-5-yl)aniline;3-Methoxy-4-(5-oxazolyl)aniline, 97%;3-Methoxy-4-(oxazol-5-yl)
    3. CAS NO:198821-79-3
    4. Molecular Formula: C10H10N2O2
    5. Molecular Weight: 190.2
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 198821-79-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 318.7±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.211±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    8. Solubility: N/A
    9. PKA: 3.03±0.10(Predicted)
    10. CAS DataBase Reference: 3-METHOXY-4-(1,3-OXAZOL-5-YL)ANILINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-METHOXY-4-(1,3-OXAZOL-5-YL)ANILINE(198821-79-3)
    12. EPA Substance Registry System: 3-METHOXY-4-(1,3-OXAZOL-5-YL)ANILINE(198821-79-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 198821-79-3(Hazardous Substances Data)

198821-79-3 Usage

Uses

Used in Pharmaceutical Industry:
3-Methoxy-4-(1,3-oxazol-5-yl)aniline is used as an intermediate in the synthesis of various pharmaceutical compounds. Its chemical reactivity allows for the creation of new drug molecules with potential therapeutic applications.
Used in Dye Industry:
In the dye industry, 3-Methoxy-4-(1,3-oxazol-5-yl)aniline is used as a building block for the production of various dyes. Its unique chemical structure contributes to the color properties and stability of the dyes.
Used in Chemical Industry:
3-Methoxy-4-(1,3-oxazol-5-yl)aniline is utilized in the chemical industry for the synthesis of a wide range of organic compounds. Its versatility as a building block enables the development of new chemical products with diverse applications.

Check Digit Verification of cas no

The CAS Registry Mumber 198821-79-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,8,2 and 1 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 198821-79:
(8*1)+(7*9)+(6*8)+(5*8)+(4*2)+(3*1)+(2*7)+(1*9)=193
193 % 10 = 3
So 198821-79-3 is a valid CAS Registry Number.

198821-79-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-METHOXY-4-(1,3-OXAZOL-5-YL)ANILINE

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:198821-79-3 SDS

198821-79-3Relevant articles and documents

Optimization of a hydrogenation process using real-time mid-IR, heat flow and gas uptake measurements

Littler, Benjamin J.,Looker, Adam R.,Blythe, Todd A.

, p. 1512 - 1517 (2010)

This paper describes using real-time mid-IR, heat flow, and gas uptake data to optimize the hydrogenation of a nitroaromatic to an aniline that had been difficult to control during a previous campaign in the pilot plant. A bimetallic Pt/V catalyst was identified that eliminated the buildup of reaction intermediates and consequently resulted in an inherently more controllable process. The real-time analytics were then used to rapidly optimize the reaction conditions and develop strategies for controlling the reaction rate in the plant should an unexpected deviation occur.

Discovery, Structure-Activity Relationships, and in Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain

Hartz, Richard A,Ahuja, Vijay T.,Nara, Susheel J.,Kumar, C.M. Vijaya,Brown, Jeffrey M.,Bristow, Linda J.,Rajamani, Ramkumar,Muckelbauer, Jodi K.,Camac, Daniel,Kiefer, Susan E.,Hunihan, Lisa,Gulianello, Michael,Lewis, Martin,Easton, Amy,Lippy, Jonathan S.,Surti, Neha,Pattipati, Sreenivasulu N.,Dokania, Manoj,Elavazhagan, Saravanan,Dandapani, Kumaran,Hamman, Brian D.,Allen, Jason,Kostich, Walter,Bronson, Joanne J.,Macor, John E.,Dzierba, Carolyn D.

, p. 11090 - 11128 (2021/08/03)

Effective treatment of chronic pain, in particular neuropathic pain, without the side effects that often accompany currently available treatment options is an area of significant unmet medical need. A phenotypic screen of mouse gene knockouts led to the d

NEW COMPOUNDS AND THEIR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF DISEASES INVOLVING THE RETINAL PIGMENT EPITHELIUM

-

, (2022/01/05)

The present invention relates to new compounds and to their use as therapeutically active substances in the treatment and/or prevention of diseases involving the retinal pigment epithelium, and in particular in the treatment and/or prevention of diseases

N-(4-(OXAZOL-5-YL)PHENYL)CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES

-

, (2020/07/15)

New compounds and to a method of treating a retinal disease that leads to photoreceptor loss or outer-retina degeneration, comprising administering compound of the formula (I) or a pharmaceutically acceptable salt, a racemic mixture, a corresponding enant

ARYL AMIDE KINASE INHIBITORS

-

, (2015/02/02)

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

QUINOLINE-BASED KINASE INHIBITORS

-

, (2015/11/02)

The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAKI.

SUBSTITUTED HETEROCYCLIC DERIVATIVES

-

, (2014/06/11)

The present invention relates to compounds of general formula (I-1) or (I-2) wherein R1 is hydrogen, lower alkyl, lower alkoxy, halogen, O(CH2)2-lower akoxy, O(CH2)2N(CH3)2, or O(CH2)-morpholinyl; R1' is hydrogen, lower alkyl, lower alkoxy, halogen, O(CH2)2-lower akoxy, O(CH2)2N(CH3)2, or O(CH2)-morpholinyl; with the proviso that both R1 and R1' may be simultaneously hydrogen, but only one of R1 and R1' is lower alkyl, lower alkoxy, halogen, O(CH2)2-lower akoxy, O(CH2)2N(CH3)2, or O(CH2)-morpholinyl; Het is a 5-or 6 membered heteroaryl group, wherein the heteroatom is selected from N, O or S; X is -CRR'-, -CRR'-NR'-, -C(O)-, -CH2-S-, -CH2-S(O)2-, CH2-O- or -CH2-CRR'-; R/R' are independently from each other hydrogen, lower alkyl, hydroxy or phenyl, or R and R' may form together with the carbon atom to which they are attached a cyclopropyl ring; R2 is lower alkyl, -C(O)O-lower alkyl, C3-6-cycloalkyl optionally substituted by lower alkyl or =O, bridged cyclohexyl or C3-6-cycloalkenyl, or is a 5-membered heteroaryl group, wherein the heteroatom is selected from N, O or S and which is optionally substituted by one or more lower alkyl, or is pyridinyl, optionally substituted by halogen or lower alkoxy; or is phenyl, optionally substituted by one or more R2', selected from halogen, cyano, S(O)2-lower alkyl, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen or amino, or is benzo[1,3]dioxolyl, naphthyl, indolyl, benzo-isoxazolyl, 2,3-dihydro-1H-indenyl, optionally substituted by lower alkoxy or by an oxo group, or is 3,4-dihydro-2H- [1,4]oxazinyl, optionally substituted by an oxo group, or is a five or six membered heterocycloalkyl group; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment or prophylaxis of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.

Development and manufacture of the inosine monophosphate dehydrogenase inhibitor merimepodib, VX-497

Looker, Adam R.,Littler, Benjamin J.,Blythe, Todd A.,Snoonian, John R.,Ansell, Graham K.,Jones, Andrew D.,Nyce, Phil,Chen, Minzhang,Neubert, Bobbianna J.

, p. 666 - 673 (2013/01/03)

A process for the manufacture of merimepodib (VX-497), an inosine monophosphate dehydrogenase (IMPDH) inhibitor, has been developed and efficiently scaled to produce clinical supply. The process comprises five steps, incorporating simple and robust chemis

A new efficient synthesis of 5-aryloxazoles from arylidene diacetates and application to the preparation of BMS-337197, a novel IMPDH inhibitor

Chen, Bang-Chi,Bednarz, Mark S.,Zhang, Huiping,Zhao, Rulin,Murali,Balu Balasubramanian, Dhar,Barrish, Joel C.

, p. 167 - 173 (2007/10/03)

A new method for the synthesis of 5-aryloxazoles is described. Treatment of arylidene diacetates with one equivalent of TosMIC reagent in the presence of excess of potassium carbonate in methanol afforded 5-aryloxazoles in "one-pot" in 90-94%. Heteroaryli

PROCESSES FOR PREPARING BIARYL UREAS AND ANALOGS THEREOF

-

Page/Page column 53; 60-61, (2008/06/13)

The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.

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