- TRITERPENOIDS FROM EUPHORBIA MACULATA
-
Two new triterpenoids were isolated together with β-amyrin acetate, taraxeryl acetate, lupenyl acetate, 3β-acetoxy-30-norlupan-20-one- α-amyrenonol and sitosterol from the whole herb of Euphorbia maculata.The structures of the new compounds were characterized as gult-5-en-3β-yl acetate, and ursa-9(11):12-dien-3β-ol on the basis of chemical and spectral evidence.Key Word Index-Euphorbia maculata; Euphorbiaceae; β-amyrin acetate; taraxeryl acetate; lupenyl acetate; 3β-acetoxy-30-norlupan-20-one; α-amyrenonol; gult-5-en-3β-yl acetate; ursa-9 (11):12-dien-3β-ol; sitosterol.
- Matsunaga, Shunyo,Tanaka, Reiko,Akagi, Masao
-
-
Read Online
- Design and synthesis of new lupeol derivatives and their α-glucosidase inhibitory and cytotoxic activities
-
A series of lupeol derivatives 2, 2a-2f, 2a-2h, 3a-3e, and 4a-4b were designed, synthesised and evaluated for their α-glucosidase inhibitory and cytotoxic activities. Among synthetic derivatives, lupeol analogues 2b and 2e containing a benzylidene chain exhibited the best activity against α-glucosidase and superior to the positive agent with the IC50 values of 29.4 ± 1.33 and 20.1 ± 0.91 μM, respectively. Lupeol analogues 2d and 3a showed weak cytotoxicity against K562 cell line with the IC50 values of 76.6 ± 2.40 and 94.4 ± 1.51 μM, respectively.
- Phan, Hoang-Vinh-Truong,Duong, Thuc-Huy,Pham, Duc-Dung,Pham, Hoang-Anh,Nguyen, Van-Kieu,Nguyen, Thi-Phuong,Nguyen, Huu-Hung,Nguyen, Ngoc-Hong,Sam-ang, Pornpat,Phontree, Kiettipum,Sichaem, Jirapast
-
-
- Novel class of hybrid natural products derived from lupeol (Part-Iii) pharmacomodulation on lupeol skeleton: Design, synthesis and biological evaluation of novel lupeol derivatives as antimalarial agents
-
Novel hybrid lupeol heterocyclics (quinoline, pyrimidine and pyrazole) were prepared. Triterpene lupeol 1 isolated from plant Crataeva nurvala was chemically modified and hybrid natural products 2a, 3a-p, 4a-p, 5a-b, 6e, 7a-b, 8a-c, 9 and 10 were evaluated for antimalarial activity in vitro. Compounds 3g, 3e, 3i, 4e, 4f, 5e, 7b and 8c showed MIC against chloroquine sensitive 3D7 strain of P. falciparum at 10 μg/ml.
- Mishra, Namita,Kumar, Satish,Khare, Pritibha,Raj, Kanwal
-
-
- Side chain oxidation of lupeol: A reinvestigation
-
Oxidation of lupeol with m-chloroperbenzoic acid yields lup-20-norketone-3β-ol (6), lup-20(29)-ene-3β,30-diol (7) and lup-20-al-3β-ol (8).Formation of the compounds 7 and 8 from lupeol is being reported for the first time.
- Roy, Kamal,Bhaduri, A. P.
-
p. 823 - 824
(2007/10/03)
-
- Lichens and Fungi. XVIII. Extractives from Pseudocyphellaria rubella
-
Twenty lupane triterpenoids including five (20RS)-epimeric pairs have been isolated from the chloroform extractives of the lichen Pseudocyphellaria rubella.The utility of g.c.-m.s. procedures in the structural elucidation of the extractives, some of which were complex mixtures is discussed.
- Corbett, R. Edward,Cong, Aimy N. T.,Holland, Patrick T.,Wilkins, Alistair L.
-
p. 461 - 468
(2007/10/02)
-