19900-84-6

Basic information

• Product Name: METHOXYMETHYL ISOTHIOCYANATE
• Synonyms: METHOXYMETHYL ISOTHIOCYANATE;[(Methoxymethyl)imino](thioxo)methane;Methane, isothiocyanatomethoxy-;Methoxymethyl isothiocyate, 96%
• CAS NO: 19900-84-6
• Molecular Formula: C₃H₅NOS
• Molecular Weight: 103.14
• Mol File: 19900-84-6.mol

Chemical Properties

• Boiling Point: 33 °C
• Flash Point: 38.1 °C
• Appearance: /
• Density: 1.11
• Vapor Pressure: 8.02mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: Keep Cold
• CAS DataBase Reference: METHOXYMETHYL ISOTHIOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHOXYMETHYL ISOTHIOCYANATE(19900-84-6)
• EPA Substance Registry System: METHOXYMETHYL ISOTHIOCYANATE(19900-84-6)

Safety Data

• Hazard Codes: T
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2810
• HazardClass: KEEP COLD, LACHRYMATOR, TOXIC
• Hazardous Substances Data: 19900-84-6(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Applications:
Methoxymethyl isothiocyanate is used as a soil fumigant and pesticide for the control of soil-borne pests and diseases. Its bioactive properties, stemming from the isothiocyanate component, make it effective in managing these issues in agricultural settings.
However, it is important to note that due to its potential toxicity and high volatility, the use of methoxymethyl isothiocyanate in these applications must be carefully managed to ensure both safety and effectiveness. This involves adhering to proper handling, storage, and application protocols to minimize risks to human health and the environment.

InChI:InChI=1/C3H5NOS/c1-5-2-4-3-6/h2H2,1H3

Upstream product

• 333-20-0 potassium thioacyanate 
• 107-30-2 chloromethyl methyl ether 
• 71-43-2 benzene 

Downstream Products

• 86311-15-1 N-methoxymethyl-N'-(2-vinylmercapto-phenyl)-thiourea 
• 59221-04-4 tri-O-benzoyl-1-(5-chloro-3-oxo-3H-[1,2,4]thiadiazol-2-yl)-β-D-1-deoxy-ribofuranose 
• 91285-82-4 3-(Methoxymethyl-thiocarbamoyl)-pyridine-2,6-dicarboxylic acid 6-amide 2-tert-butylamide 

Relevant articles and documents

Tert -Butoxide-Assisted Structural Transformation of 2-Aza-1,3,5-trienes: Fast Track to 5-Ethynyl-2-vinyl- and 2,5-Divinyl-1,3-thiazoles

Treatment of 2-aza-1,3,5-trienes, methyl N -[2-alkoxy-1-(prop-2-ynylsulfanyl)buta-1,3-dienyl]- and methyl N -[1-(allylsulfanyl)-2-alkoxybuta-1,3-dienyl]iminoformates, which are easily obtained from lithiated alkoxyallenes, methoxymethyl isothiocyanate, and propargyl or allyl bromide, with t -BuOK or t -BuONa in DMSO-THF results in the formation of 5-ethynyl-2-vinyl- and 2,5-divinyl-1,3-thiazoles. The reactions are realized under mild conditions at ca. -30 °C for 30 minutes. An unprecedented structural transformation of the (prop-2-ynylsulfanyl)- and (allylsulfanyl)-substituted 2-aza-1,3,5-trienes into 1,3-thiazoles presumably occurs via α-deprotonation of the substituent at the sulfur atom (on the SCH 2 group) followed by intramolecular [1,5]-cyclization at the imine group and aromatization (with elimination of MeOH).

Process for preparing cephalosporin derivatives

A process for the manufacture of a cephalosporin derivative of the formula I STR1 in which X is sulphur, oxygen or sulphinyl; R1 is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R2 is hydrogen or 1-6C alkyl; R3 is hydrogen or 1-6C alkyl; and the pharmaceutically-acceptable acid-addition and base-addition salts thereof, characterized by cyclization of a compound of the formula II: STR2 or a derivative thereof in which the carbonyl group is masked, or an acid-addition salt thereof, in which R4 and R5 individually have one of the values for R2 and R3, R6 is a nitrogen-protecting group and R7 is hydrogen or any one of the cephalosporin 3-carboxylic acid protecting groups known in the art; whereafter when the product from the cyclization retains the protecting group R7 (when R7 is other than hydrogen) the protecting group R7 is replaced by hydrogen by conventional means; and whereafter when the compound of the formula I is obtained in the form of the free base or salt, and a pharmaceutically-acceptable salt or free base respectively is required, any necessary conversion between free base and salt is carried out by conventional means.