199170-91-7

Basic information

• Product Name: Leucine, N-acetyl-4-methyl- (9CI)
• Synonyms: Leucine, N-acetyl-4-methyl- (9CI)
• CAS NO: 199170-91-7
• Molecular Formula: C9H17NO3
• Molecular Weight: 187.24
• Mol File: 199170-91-7.mol

Chemical Properties

• Boiling Point: 371.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.051±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.66±0.10(Predicted)
• CAS DataBase Reference: Leucine, N-acetyl-4-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Leucine, N-acetyl-4-methyl- (9CI)(199170-91-7)
• EPA Substance Registry System: Leucine, N-acetyl-4-methyl- (9CI)(199170-91-7)

Safety Data

• Hazardous Substances Data: 199170-91-7(Hazardous Substances Data)

Usage

Uses

Used in Nutritional Supplements:
Leucine, N-acetyl-4-methyl(9CI) is utilized as a nutritional supplement to support muscle growth and recovery. It is particularly beneficial for athletes and individuals engaged in regular physical activity, as it aids in the synthesis of muscle proteins and assists in the recuperation process following exercise.
Used in Antioxidant Formulations:
Due to its potential antioxidant properties, Leucine, N-acetyl-4-methyl(9CI) is employed in antioxidant formulations designed to protect cells from oxidative damage and inflammation. This application is relevant in the health and wellness industry, where maintaining cellular health and reducing inflammation are key objectives.
Used in Pharmaceutical Development:
Leucine, N-acetyl-4-methyl (9CI) is also used in pharmaceutical development for its potential therapeutic applications. Given its role in muscle protein synthesis and recovery, as well as its antioxidant potential, it may be incorporated into medications aimed at treating muscle-related conditions or enhancing physical performance.
Used in Research:
In the scientific research field, Leucine, N-acetyl-4-methyl(9CI) serves as a subject of study to further understand its physiological effects and potential benefits in human health and performance. This research is crucial for the development of new therapies and interventions based on the compound's unique properties.

Upstream product

• 108-24-7 acetic anhydride 
• 57224-50-7 (S)-2-Amino-4,4-dimethyl-pentanoic acid 
• 60122-72-7 4,4-Dimethyl-2(R)-aminopentanoic acid 
• 34906-87-1 4,4-dimethyl-2-oxo-pentanoic acid 
• 5429-56-1 N-Acetamidoacrylic acid 
• 38442-51-2 tert-butylmercury chloride 
• 88319-40-8 N-formyl-L-neopentylglycine 
• 88319-39-5 2-carbamoyl-4,4-dimethylpentanoic acid 
• 479353-90-7 2-amino-4,4-dimethyl-pentanenitrile 
• 88319-38-4 2-cyano-4,4-dimethylpentanoic acid 
• 7065-46-5 3,3-dimethylbutanoic acid chloride 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 39168-28-0 (E)-2-cyano-4,4-dimethyl-pent-2-enoic acid 
• 57224-50-7 L-neopentylglycine 

Relevant articles and documents

Direct monitoring of biocatalytic deacetylation of amino acid substrates by1H NMR reveals fine details of substrate specificity

Amino acids are key synthetic building blocks that can be prepared in an enantiopure form by biocatalytic methods. We show that thel-selective ornithine deacetylase ArgE catalyses hydrolysis of a wide-range ofN-acyl-amino acid substrates. This activity was revealed by1H NMR spectroscopy that monitored the appearance of the well resolved signal of the acetate product. Furthermore, the assay was used to probe the subtle structural selectivity of the biocatalyst using a substrate that could adopt different rotameric conformations.

DL-neopentyl glycine intermediate and preparation method thereof and preparation method of derivative based on intermediate

The invention relates to the field of amino acid preparation, in particular to a DL-neopentyl glycine intermediate and a preparation method thereof and a preparation method of a derivative based on the intermediate. The preparation method of the DL-neopentyl glycine intermediate comprises an acetylation reaction, a condensation reaction, a hydrolysis reaction, an oximation reaction and a reductionreaction, and then a corresponding derivative is obtained through the acetylation reaction and resolution. According to the preparation method, the reaction time is shortened, the reaction is more thorough and the DL-neopentyl glycine can be obtained; two methods for preparing the derivative D-neopentyl glycine and the derivative L-neopentyl glycine are obtained at the same time, the prepared product is high in purity, secondary refining is not needed, the production cost is reduced, and industrial large-scale production is facilitated.

Method for synthesizing chiral N-substituted-alpha-amino acid compound through chemical resolution

The invention belongs to the technical field of preparation of N-substituted-alpha-amino acid compounds, and particularly relates to a method for synthesizing a chiral N-substituted-alpha-amino acid compound through chemical resolution. The method comprises the following steps: mixing a racemate N-substituted-alpha-amino acid compound with phenylglycinol to form a salt, and adding an acid for neutralization to obtain a single-configuration chiral target product, wherein the N-substituted-alpha-amino acid compound is N-substituted-2-amino-4,4-dimethyl valeric acid, and an N-substituted amino protecting group is an alkoxycarbonyl group, an enoxycarbonyl group, an aryloxycarbonyl group or an alkylacyl group. According to the method, chiral phenylglycinol which is low in cost and stable in property is used as a resolution reagent, and N-substituted alpha-amyl amino acid can be well resolved; and R-configuration or S-configuration enantiomers are respectively obtained. The method is high inyield, good in purity, low in cost and suitable for industrial production.

Solid-phase synthesis of α-amino acids by radical addition to a dehydroalanine derivative

The first synthesis of N-acetyl-a-amino acids by radical addition on solid support to commercially available 2-acetamidoacrylic acid using the mercury method is described. The reaction proceeds in acceptable chemical efficiency (49-60%) depending on the nature of the mercury halide agent. Cleavage by mild acid treatment released the product from the solid support in excellent purity.

PEPTIDES CONTAINING A NEOPENTYLGLYCINE RESIDUE

Neopentylglycine (III, 2-amino-4,4-dimethylpentanoic acid) was synthesized in both enantiomeric forms.Using the conventional methods of peptide synthesis, L-prolyl-L-neopentylglycylglycine amide (VII), the diastereomeric cyclodipeptides cyclo(L-neopentylglycyl-L-prolyl) (IXa) and cyclo(D-neopentylglycyl-L-prolyl) (IXb) and also N-acetyl-L-neopentylglycine methylamide (X) were prepared as models for further studies on physical properties and conformation of peptides.