- Design, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents
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A novel series of N-arylpyrazole derivatives (5a-5d, 7a-7c) has been designed and synthesized via aromatic substitution reaction of N-nonsubstituted pyrazoles with 4-fluoronitrobenzene in the presence of base. The structures of these compounds were establ
- Xu, Shengjie,Li, Shenghui,Tang, Yonghe,Zhang, Jinchao,Wang, Shuxiang,Zhou, Chuanqi,Li, Xiaoliu
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p. 5610 - 5616
(2013/12/04)
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- A simple and environmentally benign synthesis of polypyridine- polycarboxylic acids
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An oxidation method using dilute nitric acid solutions under solvothermal conditions has been developed to synthesise a series of polypyridine- polycarboxylic acids. It has been successfully applied to a range of methyl substituted polypyridines including symmetrical and asymmetrical 2,2′-bipyridines; 2,2′:6′,2″-terpyridines and; 2,2′:6′,2″:6″,2?-tetra-pyridines and yields crystalline polypyridine-polycarboxylic acids in a single step. Simple product recovery through filtration yields a recyclable filtrate. More forcing conditions led to demethylation of the polypyridine ligand most probably via decarboxylation. This simple approach avoids potentially harmful metal-based oxidants and negates any issues associated with the disposal of their resultant (hazardous) waste.
- Kelly, Niamh R.,Goetz, Sandrine,Hawes, Chris S.,Kruger, Paul E.
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scheme or table
p. 995 - 998
(2011/03/21)
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- HETEROARYLPIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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The present invention is directed to compounds of the formula (I): (wherein R>12345610 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
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