Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-α-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors
A series of highly potent and specific fibrinogen receptor antagonists have been discovered and optimized through structural modification of the novel amidinoindole and benzofuran compounds, I and II. Systematic linker optimization afforded the amidinoben
Su, Ting,Naughton, Mary Ann H.,Smyth, Mark S.,Rose, Jack W.,Arfsten, Ann E.,McCowan, Jefferson R.,Jakubowski, Joseph A.,Wyss, Virginia L.,Ruterbories, Kenneth J.,Sall, Daniel J.,Scarborough, Robert M.