- SYNTHESIS AND PROPERTIES OF PEPTIDE FRAGMENTS OF THE S-REGION OF THE SURFACE PROTEIN OF THE HEPTATITIS B VIRUS
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A peptide fragment with the 140-146 sequence of the main component of the surface protein of the hepatitis B virus (HBsAG) and a number of its structural analogues have been synthesized by the classical method in solution.Conjugates of the peptides synthesized with bovine serum albumin and with a synthetic polypeptide analogue of polytuftsin have been obtained.The ability of the preparations to bind antibodies from the blood sera of hepatitis B patients has been studied.The possibility has been shown of their use for revealing antibodies to the heptatitis B virus in solid-phase enzyme-mediated immunoassay.
- Kuranova, I. L.,Churkina, S. I.,Os'mak, A. V.,Filonova, E. B.,Lyudmirova, V. L.,Noskova, O. V.
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p. 355 - 361
(2007/10/02)
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- Novel substrate peptides
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A peptide substrate for myristoylating enzymes is disclosed having an amino acid sequence selected from the group consisting of the following sequences or a physiologically acceptable amide or salt derivative thereof: STR1 wherein R=Ala, Asn, Gln or Ser; S=Ala, Arg, Gln, Glu, Phe or Ser; T=Ala or Lys; W=Ala or Ser; X=Ala, Tyr, or Lys; Y=Arg or Pro; and Z=Arg, Leu or Lys.
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