Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones
The acylation of aryl halides to prepare aryl ketones without metal catalyst represents an important yet challenging topic towards more sustainable ketone synthesis. Herein, we describe a simple and efficient metal-free protocol for the acylation of aryl halides with diketone under the irradiation of light utilizing N-methylpiperidine as base under an air atmosphere. This reaction can tolerate a wide range of functional groups and the corresponding ketones can be obtained in modest to good yields.
The invention provides compounds of the formula (3): or a pharmaceutically acceptable salt or tautomer thereof. The compounds are useful in the treatment of cancers.
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(2018/11/22)
Ni-catalyzed activation of α-chloroesters: a simple method for the synthesis of α-arylesters and β-hydroxyesters
Coupling reactions of α-chloroesters with aryl halides (α-arylation) or carbonyl compounds (Reformatsky) using nickel catalyst allow, under mild conditions, the preparation of various functionalized aryl propionic acid derivatives or β-hydroxyesters. In the synthesis of aryl propionic acid derivatives, the process is efficient with aryl halides bearing either electron-withdrawing or electron-donating groups.
Durandetti, Muriel,Gosmini, Corinne,Périchon, Jacques
p. 1146 - 1153
(2007/10/03)
Practical synthesis of acetophenones from phenoltriflates
A new practical method for the preparation of acetophenone from aryl triflates is reported. The acyl group is installed by a mixture of SnMe4, Pd(0) and CO (balloon), using a three-component procedure.
Garrido, Fabrice,Raeppel, Stéphane,Mann, André,Lautens, Mark
p. 265 - 266
(2007/10/03)
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