20051-06-3

Usage

Synthesis Reference(s)

Tetrahedron Letters, 42, p. 265, 2001 DOI: 10.1016/S0040-4039(00)01935-3

InChI:InChI=1/C11H12O3/c1-8(12)10-5-3-9(4-6-10)7-11(13)14-2/h3-6H,7H2,1-2H3

Upstream product

• 75-36-5 acetyl chloride 
• 101-41-7 benzeneacetic acid methyl ester 
• 201230-82-2 carbon monoxide 
• 594-27-4 tetramethylstannane 
• 147283-85-0 (4-Trifluoromethanesulfonyloxy-phenyl)-acetic acid methyl ester 
• 99-90-1 para-bromoacetophenone 
• 96-34-4 methyl chloroacetate 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 431-03-8 dimethylglyoxal 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 

Downstream Products

• 7398-47-2 methyl 2-(4-(1-hydroxyethyl)phenyl)acetate 
• 100863-78-3 [4-(1-isopropoxy-ethyl)-phenyl]-acetic acid methyl ester 
• 84325-98-4 p-Methoxycarbonylmethylphenylacetyl bromide 
• 62667-42-9 4-vinyl(phenyl)acetic acid methyl ester 
• 84326-00-1 Ethyl p-methoxycarbonylmethylphenylglyoxylate 
• 84326-02-3 [4-(2-Oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 84326-04-5 [4-(6-Methyl-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 84326-07-8 Methyl 4-(6,8-dimethyl-2H-1,4-benzoxazin-2-one-3-yl) phenyl acetate 
• 84326-03-4 [4-(6-Chloro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 84326-06-7 [4-(8-Chloro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 84326-05-6 [4-(6-Nitro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 15824-17-6 4-phenethylstyrene 
• 62667-41-8 p-Vinylphenylperessigsaeure-tert.-butylester 
• 46122-65-0 4-vinylbenzeneacetic acid 

Relevant academic research and scientific papers

Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones

The acylation of aryl halides to prepare aryl ketones without metal catalyst represents an important yet challenging topic towards more sustainable ketone synthesis. Herein, we describe a simple and efficient metal-free protocol for the acylation of aryl halides with diketone under the irradiation of light utilizing N-methylpiperidine as base under an air atmosphere. This reaction can tolerate a wide range of functional groups and the corresponding ketones can be obtained in modest to good yields.

PYRROLE DERIVATIVES AS PLK1 INHIBITORS

The invention provides compounds of the formula (3): or a pharmaceutically acceptable salt or tautomer thereof. The compounds are useful in the treatment of cancers.

Ni-catalyzed activation of α-chloroesters: a simple method for the synthesis of α-arylesters and β-hydroxyesters

Coupling reactions of α-chloroesters with aryl halides (α-arylation) or carbonyl compounds (Reformatsky) using nickel catalyst allow, under mild conditions, the preparation of various functionalized aryl propionic acid derivatives or β-hydroxyesters. In the synthesis of aryl propionic acid derivatives, the process is efficient with aryl halides bearing either electron-withdrawing or electron-donating groups.

Practical synthesis of acetophenones from phenoltriflates

A new practical method for the preparation of acetophenone from aryl triflates is reported. The acyl group is installed by a mixture of SnMe4, Pd(0) and CO (balloon), using a three-component procedure.